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Clinical Trial Summary

This is a pilot study, phase III, multi-centre, double blind, randomized controlled trial of patients with traumatic brain injury (TBI).


Clinical Trial Description

Patients with severe brain injury are at risk for developing blood clots in their legs, which can travel to the lungs. This potentially serious complication is known as venous thromboembolism (VTE). Anticoagulants are commonly used to prevent VTE in hospital patients. However, in patients with major head injury, anticoagulant prevention is commonly delayed for the fear that it can potentially lead to further bleeding in the brain. Another method that aims to prevent blood clots involves the use of sequential compression device (SCD) that compress the legs and increase the flow of blood in the leg veins. This study will compare results from patients who receive the SCDs only to those who receive both SCD and anticoagulants. The outcome of this study will provide information about how best to prevent blood clots while not increase brain bleeding after head injury. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03559114
Study type Interventional
Source Sunnybrook Health Sciences Centre
Contact Farhad Pirouzmand, MD, MSc, FRCSC
Phone 416-480-6100
Email farhad.pirouzmand@sunnybrook.ca
Status Recruiting
Phase Phase 3
Start date July 19, 2018
Completion date December 2027

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