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Rehabilitation of Working Memory and Brain Plasticity After Traumatic Brain Injury: Plastim-MDTC — Plastim-MDTC  

Traumatic Brain Injury Clinical Trial

Official title:
Rehabilitation of Working Memory After Traumatic Brain Injury: Pilot Study of Brain Plasticity in Multimodal Advanced MRI

Clinical Trial Summary

The aim of this study is to assess the brain correlates, as assessed with multimodal MRI, of working memory training in patients with severe traumatic brain injury (TBI)

Clinical Trial Description

This is a pilot feasibility study. Patients with subacute/chronic (> 6 months) severe TBI will be included if they suffer from a deficit in working memory. They will receive a specific hierarchical training of working memory (3 sessions per week during three months), according to a previously described methodology.

A multimodal MRI will be performed at neuroSpin center (CEA, Orsay, France) before and after cognitive training, including: structural imaging (T1, FLAIR and diffusion tensor imaging, DTI); functional connectivity at rest; and functional activation during a working memory task (n-back).

Behavioral and imaging changes after training will be analysed individually and compared to a group of healthy controls matched for age, gender and education. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03513133
Study type Interventional
Source Centre d'Investigation Clinique et Technologique 805
Contact Philippe AZOUVI, MD-PhD
Phone 0033 147107074
Email philippe.azouvi@aphp.fr
Status Recruiting
Phase N/A
Start date July 1, 2017
Completion date December 31, 2019
View Details
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