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Controlling Hyperadrenergic Activity in Neurologic Injury — CHAIN  

Traumatic Brain Injury Clinical Trial

Official title:
Controlling Hyperadrenergic Activity in Neurologic Injury

Clinical Trial Summary

Traumatic brain injury (TBI) is frequently associated with a hyperadrenergic state accompanied by elevated levels of plasma catecholamines. In its more severe presentation, the hyperadrenergic state presents as dysautonomia, which is characterized by paroxysmal alteration in vital signs, including tachycardia. The investigators hypothesize that intravenous (IV) esmolol is as effective at controlling heart rate in hyperadrenergic states as oral propranolol, which is the standard of care. Our primary endpoint is efficacy of IV esmolol vs a PRN regimen of intermittent B-blockade in controlling heart rate below a pre-specified level (< 100 bpm) after Traumatic Brain Injury (TBI) or hemorrhagic neurologic injury. Heart rates will be recorded continuously as well as hourly.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01343329
Study type Interventional
Source Johns Hopkins University
Contact
Status Withdrawn
Phase Phase 1/Phase 2
Start date July 2011
Completion date February 14, 2014
View Details
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