Anterior Pituitary Hormone Replacement in Traumatic Brain Injury

Status Completed

Clinical Trial Summary

Fifteen to twenty percent of adults who suffer a traumatic brain injury (TBI) that requires hospitalization and rehabilitation have been found to have growth hormone (GH) deficiency by GH stimulation testing. Moreover, abnormalities have also been established for the cortisol and thyroid axis. The hypothesis of this proposal is that hormone replacement in TBI patients with documented abnormalities in the GH, thyroid, or cortisol axis will improve muscle function, body composition, aerobic capacity (GH) and tests of neuropsychologic function (GH, thyroid, cortisol).

Clinical Trial Description

This protocol is designed to screen and detect evidence of pituitary hormone deficiency in adults following traumatic brain injury. Growth hormone deficiency will be replaced for a period of one year. Subject will not be screened until at least one year following brain injury to allow for natural recovery of hormone function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00957671
Study type	Interventional
Source	The University of Texas Medical Branch, Galveston
Contact
Status	Completed
Phase	Phase 4
Start date	November 2003
Completion date	October 2015

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