Traumatic Brain Injury Clinical Trial
Official title:
The Predictive Value of Clinical and Immunological Factors in the Development of Pneumonia After Traumatic Brain Injury
The development of pneumonia and other infections is one of the most common complications of
a traumatic brain injury (TBI). Prior studies have also found that patients suffering from
TBI also develop immune dysfunction consistent with an immunosuppressed state shortly after
the traumatic event. Specifically, it has been shown that patients with a TBI have impaired
delayed type hypersensitivity (DTH), cellular immunity and humoral immunity. The humoral arm
of the immune system is particularly involved in defending the host against extracellular
bacteria and is primarily composed of B-cells, immunoglobulins and complement. Surgery and
trauma impair the clonal expansion of antibody producing B lymphocytes causing
hypogammaglobulinemia, through a mechanism involving T lymphocytes. In addition, during the
systemic inflammatory process, pro-inflammatory cytokines such as tumor necrosis factor
alpha (TNF-alpha), interleukin 1 (IL-1beta) and interleukin 6 (IL-6) are released. Nuclear
factor kappa beta (NF-kB) is a transcriptional regulatory protein that is involved in the
expression of proinflammatory cytokines and appears to act at a critical step in the
transcription of many proinflammatory genes.
The hypothesis of this study is that the hypogammaglobulinemia from the immune dysfunction
and the induction of NF-kB from the inflammatory process are, in part, responsible for the
development of pneumonia and other infectious complications identified after TBI. This study
has two specific aims: The primary specific aim of this study is to determine the
association between serum immunoglobulin or NF-kB levels and the development of pneumonia in
patients suffering from traumatic brain injury (TBI). The secondary specific aim of this
study is to determine the relative contribution of clinical variables such as APACHE II-III
Score and Injury Severity Score as compared to immunological variables (serum
immunoglobulins and NF-kB) to the development of pneumonia in patients suffering from TBI.
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03052712 -
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
|
N/A | |
| Recruiting |
NCT05503316 -
The Roll of Balance Confidence in Gait Rehabilitation in Persons With a Lesion of the Central Nervous System
|
N/A | |
| Completed |
NCT04356963 -
Adjunct VR Pain Management in Acute Brain Injury
|
N/A | |
| Completed |
NCT03418129 -
Neuromodulatory Treatments for Pain Management in TBI
|
N/A | |
| Terminated |
NCT03698747 -
Myelin Imaging in Concussed High School Football Players
|
||
| Recruiting |
NCT05130658 -
Study to Improve Ambulation in Individuals With TBI Using Virtual Reality -Based Treadmill Training
|
N/A | |
| Recruiting |
NCT04560946 -
Personalized, Augmented Cognitive Training (PACT) for Service Members and Veterans With a History of TBI
|
N/A | |
| Completed |
NCT05160194 -
Gaining Real-Life Skills Over the Web
|
N/A | |
| Recruiting |
NCT02059941 -
Managing Severe Traumatic Brain Injury (TBI) Without Intracranial Pressure Monitoring (ICP) Monitoring Guidelines
|
N/A | |
| Recruiting |
NCT03940443 -
Differences in Mortality and Morbidity in Patients Suffering a Time-critical Condition Between GEMS and HEMS
|
||
| Recruiting |
NCT03937947 -
Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study
|
||
| Completed |
NCT04465019 -
Exoskeleton Rehabilitation on TBI
|
||
| Recruiting |
NCT04530955 -
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
|
N/A | |
| Recruiting |
NCT03899532 -
Remote Ischemic Conditioning in Traumatic Brain Injury
|
N/A | |
| Suspended |
NCT04244058 -
Changes in Glutamatergic Neurotransmission of Severe TBI Patients
|
Early Phase 1 | |
| Completed |
NCT03307070 -
Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury
|
N/A | |
| Recruiting |
NCT04274777 -
The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders
|
||
| Withdrawn |
NCT04199130 -
Cognitive Rehabilitation and Brain Activity of Attention-Control Impairment in TBI
|
N/A | |
| Withdrawn |
NCT05062148 -
Fundamental and Applied Concussion Recovery Modality Research and Development: Applications for the Enhanced Recovery
|
N/A | |
| Withdrawn |
NCT03626727 -
Evaluation of the Efficacy of Sodium Oxybate (Xyrem®) in Treatment of Post-traumatic Narcolepsy and Post-traumatic Hypersomnia
|
Early Phase 1 |