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Transposition of Great Vessels clinical trials

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NCT ID: NCT00374088 Completed - Clinical trials for Congenital Heart Disease

N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)

Start date: February 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether intravenous N-acetylcysteine (also known as Acetadote), an antioxidant medication that has been used for years to treat Tylenol overdose, helps prevent heart dysfunction in the early postoperative period following congenital heart surgery. Children undergoing major heart surgery, such as the arterial switch operation, routinely develop temporary heart dysfunction in the first 12-24 hours after surgery. This heart dysfunction may be severe and contributes to an increased risk for death or prolonged hospitalization. Current standard treatments include intravenous medications such as dopamine, epinephrine, and vasopressin that support your child's blood pressure and heart function. Unfortunately, high doses of these medications have the potential to cause severe side effects including loss of fingers and toes, liver and kidney dysfunction, and heart rhythm abnormalities. Our goal is to find a way to reduce heart dysfunction after major heart surgery in order to promote a smoother postoperative period, and reduce the risks associated with heart operations in children.

NCT ID: NCT00313352 Completed - Clinical trials for Congenital Disorders

Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular Function

Start date: January 1997
Phase: N/A
Study type: Observational

The purpose of this chart review study is to examine the effects of beta -adrenergic blocking agents on systemic ventricular dimensions, systemic atrioventricular valve function and exercise tolerance in patients with transposition of the great arteries (TGA) and systemic ventricular dysfunction.

NCT ID: NCT00199771 Completed - Clinical trials for Heart Defects, Congenital

Hypertonic Saline Dextran in Pediatric Cardiac Surgery

Start date: June 2003
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether infusion of hypertonic saline dextran attenuates the inflammatory response and the water overload, during and after major cardiac surgery in small children.

NCT ID: NCT00006183 Completed - Clinical trials for Cardiovascular Diseases

Comparison of Hematocrit Levels in Infant Heart Surgery

Start date: July 2000
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effects of diluted hematocrit (HCT) levels of 35% versus 25% during hypothermic cardiopulmonary bypass (CPB) in infants with d-transposition of the great arteries, a malformation of the heart vessels.

NCT ID: NCT00005190 Completed - Clinical trials for Cardiovascular Diseases

Reproduction and Survival After Cardiac Defect Repair

Start date: July 1986
Phase: N/A
Study type: Observational

To create a registry of all Oregon children undergoing surgical repair of congenital heart disease since 1958 in order to determine mortality, morbidity, and disability after surgery and to assess the safety of pregnancy in women with corrected congenital heart disease and the risk of prematurity and occurrence of congenital heart defects in offspring.

NCT ID: NCT00000470 Completed - Clinical trials for Cardiovascular Diseases

Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest

BCAS
Start date: December 1988
Phase: Phase 3
Study type: Interventional

To compare the influence of two surgical anesthetic techniques, hypothermia with circulatory arrest or hypothermia with low-flow bypass perfusion, on neurologic functioning in infants undergoing heart surgery.