NCAMR-CAMR Allosure Study

Status Enrolling by invitation

Clinical Trial Summary

Heart Transplant recipients at Tampa General Hospital heart transplant program who have pAMR1(H+) or pAMR1(I+) rejection will have a DD-cfDNA /GEP sample obtained at the time of the rejection. The DD-cfDNA/GEP will then be drawn every month post treatment for the rejection until the DD-cfDNA/GEP level returns to normal. A total of fifteen recipients with pAMR1(H+) and fifteen recipients with pAMR1(I+) rejection will be included in the study which will last two years. The presence of HLA antibodies (DSA's) and the titers, presence of Autoantibodies, the measurement of cytokines IL2, IL4, IL6, IL 10, IL 17, TNF alpha, TGF beta, the presence of coronary artery vasculopathy, the time from transplant to the onset of the episode of AMR, time to resolution, the response to treatment and comparison to the DD-cfDNA/GEP level with pAMR2 and pAMR 3 rejections will be analyzed.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Transplant Failure

Clinical Trial Details

NCT number	NCT04217343
Study type	Observational
Source	Tampa General Hospital
Contact
Status	Enrolling by invitation
Phase
Start date	March 5, 2020
Completion date	March 5, 2023

View Details

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