Clinical Trials Logo

Clinical Trial Summary

Heart Transplant recipients at Tampa General Hospital heart transplant program who have pAMR1(H+) or pAMR1(I+) rejection will have a DD-cfDNA /GEP sample obtained at the time of the rejection. The DD-cfDNA/GEP will then be drawn every month post treatment for the rejection until the DD-cfDNA/GEP level returns to normal. A total of fifteen recipients with pAMR1(H+) and fifteen recipients with pAMR1(I+) rejection will be included in the study which will last two years. The presence of HLA antibodies (DSA's) and the titers, presence of Autoantibodies, the measurement of cytokines IL2, IL4, IL6, IL 10, IL 17, TNF alpha, TGF beta, the presence of coronary artery vasculopathy, the time from transplant to the onset of the episode of AMR, time to resolution, the response to treatment and comparison to the DD-cfDNA/GEP level with pAMR2 and pAMR 3 rejections will be analyzed.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04217343
Study type Observational
Source Tampa General Hospital
Contact
Status Enrolling by invitation
Phase
Start date March 5, 2020
Completion date March 5, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT06080490 - Tacrolimus Blood Concentration and Transplant-related Outcomes in Pediatric HSCT Recipients
Recruiting NCT06116721 - Evaluation of APOL1 Gene Variants in Kidney Donors and Their Impact on Long-term Renal Function in Donors and Recipients
Completed NCT04783818 - Adjuvant Radiotherapy's Effect on One and Two Stages Prosthetic Breast Reconstruction and on Autologous Reconstruction
Completed NCT04854525 - Breast Reconstruction in Previously Irradiated Breast
Recruiting NCT06346665 - The Transplant Cohort of the German Center for Infection Research
Completed NCT03723317 - Associated Balance of Risk Score - Comprehensive Complication Index for the Prediction of Post-transplant Survival
Active, not recruiting NCT03882164 - Blood-Bile Ratio Tacrolimus After Liver Transplantation
Recruiting NCT04360031 - The Effects of Microbiota Composition on Immunosuppression Protocols in Transplantation
Active, not recruiting NCT03575910 - HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
Recruiting NCT03587493 - T-lymphocytes CD8+/HLA-DR+ and Acute Rejection After Lung Transplantation N/A
Active, not recruiting NCT05184426 - MuLtimodality EvaluatiOn of aNtibody mEdiated Damage in Heart Transplantation (LEONE-HT)