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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT06403176
Other study ID # plasma multiomics
Secondary ID
Status Completed
Phase
First received
Last updated
Start date May 1, 2022
Est. completion date April 30, 2024

Study information

Verified date March 2022
Source First Affiliated Hospital of Zhejiang University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

In order to determine the abnormal cerebral metabolism in the pathological state, we compared the blood of internal jugular vein, superior vena cava and radial artery during central venous catheterization. Metabonomics, proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness. At the same time, we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.


Description:

Background:It is unclear what substances the brain needs to ingest for its activity under pathological conditions Method:The uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein blood;The characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood. Compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis. Objective:By analyzing different substances, this paper briefly describes the pathological mechanism of patients with disorders of consciousness, and looks for potential prognostic biomarkers.


Recruitment information / eligibility

Status Completed
Enrollment 100
Est. completion date April 30, 2024
Est. primary completion date March 30, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: 1.Patients with consciousness disorder caused by various severe brain injuries Exclusion Criteria: 1. Patients who have been judged brain dead 2. There are persistent epileptic activity, inhibition or seizure inhibition patterns 3. Recent fever, abnormal liver and kidney function 4. Previous history of neurological or mental illness 5. Have a history of tumor 6. Inflammatory bowel diseases, hyperlipidemia, gastritis

Study Design


Intervention

Other:
No intervention
No intervention

Locations

Country Name City State
China The First Affiliated Hospital of Zhejiang University Hanzhou Zhejiang

Sponsors (1)

Lead Sponsor Collaborator
First Affiliated Hospital of Zhejiang University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Patient clinical outcome The patients were followed up for 12 months after blood collection to observe the clinical outcome 12 months
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