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Tolerability clinical trials

View clinical trials related to Tolerability.

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NCT ID: NCT02107885 Completed - Pharmacokinetics Clinical Trials

Single Ascending Dose Study Using DS-1971 to Assess Safety, Tolerability, and Pharmacokinetics in Healthy Participants.

Start date: March 2014
Phase: Phase 1
Study type: Interventional

This is a randomised, double-blind, placebo-controlled and ascending single dose study. It is hypothesised that single oral doses of DS-1971a within the planned dose range will be safe and well tolerated by healthy male subjects.

NCT ID: NCT02082158 Completed - Comfort Clinical Trials

Assessment of Novel Respiratory Protective Devices in Healthcare

Start date: July 2014
Phase: N/A
Study type: Interventional

This VA-based study will obtain feedback from healthcare workers via validated survey instrument on the comfort and tolerability of wearing current models of N95 respirators and novel respirator designs currently in development. There will be 4 novel respirators and 1 commonly used respirator (not locally used) to compare to a locally used respirator, which is familiar to participants. Comparisons will be examined between each of the first 5 models with the locally used control using Dunnett's t-test.

NCT ID: NCT02054754 Completed - Cancer Clinical Trials

Assessment of Single Doses of Oral Dexanabinol in Healthy Subjects

Start date: January 2014
Phase: Phase 1
Study type: Interventional

The purpose of this study is to test the safety and observe the pharmacokinetics (distribution and elimination of the drug) of the compound dexanabinol (ETS2101) in healthy male subjects following a single oral dose.

NCT ID: NCT01981928 Completed - Safety Clinical Trials

A Clinical Trial to Investigate Safety and Tolerability of ASP7962 in Healthy Humans

Start date: November 2013
Phase: Phase 1
Study type: Interventional

The purpose of the study is to see how safe the study drug is and how well it is tolerated after dosing. The study will also investigate how the study drug is taken up, metabolized (chemically broken down), distributed through the body and excreted. A further aim is to look at how this process is possibly altered by food by giving the study drug in the presence and absence of meals.

NCT ID: NCT01959685 Completed - Pharmacokinetics Clinical Trials

A Dose Escalating Study to Determine the Tolerability and PK of a Single Dose of Androxal

Start date: October 2013
Phase: Phase 1
Study type: Interventional

To determine the tolerability and pharmacokinetics (PK) of a single dose of Androxal in healthy adult male subjects as the dose to be investigated in a thorough QT interval/corrected QT interval (QT/QTc) study.

NCT ID: NCT01954589 Completed - Pharmacokinetics Clinical Trials

Single-ascending Dose Study to Investigate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of ACT-462206

Start date: November 2011
Phase: Phase 1
Study type: Interventional

A study of ACT-462206 to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamic of ascending single doses of ACT-462206, a novel dual orexin receptor antagonist in healthy male subjects.

NCT ID: NCT01841801 Completed - Tolerability Clinical Trials

Evaluation of Experimental and Commercial Air-Activated, Adhesive Backed Heat Patches

Start date: October 2012
Phase: N/A
Study type: Interventional

To assess the safety and tolerability for the extended wear of an experimental air-activated self adhesive patch.

NCT ID: NCT01841788 Completed - Tolerability Clinical Trials

Evaluation of Experimental Heat Patch

Start date: October 2012
Phase: N/A
Study type: Interventional

A disposable, air-activated, adhesive backed heat patch is being developed to provide temporary relief from minor muscular ache and joint pains associated with overexertion strains and sprains as well as minor pain associated with arthritis. The aim of the study is to determine the safety and tolerability of the patch during normal wear conditions.

NCT ID: NCT01818869 Completed - Healthy Subjects Clinical Trials

To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects

Start date: January 2014
Phase: Phase 1
Study type: Interventional

This study will investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of AZD8848 in healthy subjects.

NCT ID: NCT01703871 Active, not recruiting - Pain Clinical Trials

Music During Diagnostic Hysteroscopy

Start date: September 2012
Phase: N/A
Study type: Observational

Office Hysteroscopy is associated with a level of anxiety that could condition tolerability of the procedure by the patient. The aim of this study is to evaluate the impact of music on anxiety state, expected and received pain by patients during office hysteroscopy.