Tobacco Use Clinical Trial
Official title:
Investigating Stress-Potentiated Memory Updating as a Novel Intervention for Non-Treatment Seeking Smokers
Interventions to disrupt memory reconsolidation have held promise for the treatment of stress- and anxiety-related disorders. In the present study, the investigators will examine whether an intervention based on these principles, called memory updating, could be adapted for reward-seeking behaviors. To test this, non-treatment seeking tobacco smokers will be exposed to smoking cues and/or stress, two stimuli known to trigger smoking. It is predicted that exposure to a stress task will enhance the cues' motivational salience and yield greater susceptibility to the memory updating procedure. As an add-on, the investigators will examine COVID-associated changes in substance use and whether participants in the memory updating groups might be more resilient to these effects. It is predicted that the changes in substance use will depend on whether the substances are used primarily in social settings.
Status | Active, not recruiting |
Enrollment | 76 |
Est. completion date | January 31, 2022 |
Est. primary completion date | May 1, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Scoring 5 or higher on the Fagerström Test for Cigarette Dependence - Willingness to abstain from smoking for 4 hours prior to each laboratory visit Exclusion Criteria: - Currently using cigarette cessation products - Endocrinological problems - Significant mental or physical health conditions - Pregnancy |
Country | Name | City | State |
---|---|---|---|
Canada | McGill University | Montreal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Marco Leyton |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Change in stress- and/or cue-induced mood during the intervention and at test sessions 1, 2 and 3 | Participants will be asked to complete a mood questionnaire at several time points during the intervention and at test sessions 1, 2 and 3 | Multiple time points during the intervention and test sessions at 24 hours, 2 weeks and 6 weeks post-intervention | |
Other | Change in cigarette use over the course of the procedure as a function of personality factors, childhood trauma, perceived stress, mood and/or cigarette withdrawal | Participants will be asked to complete self-report questionnaires about their personality traits, traumatic childhood experiences, perceived stress, current mood states and cigarette withdrawal symptoms | Multiple time points at baseline, during the intervention, at test sessions (24 hours, 2 weeks and 6 weeks post-intervention) and telephone follow-ups (6 months post-intervention) | |
Primary | Change in cigarettes smoked per day from the pre-intervention baseline to test sessions 2 and 3 given two and six weeks post-intervention | A journal is given to participants to record their cigarette use behaviour every day for a month and a half | At the end of test session 1 (24 hours post-intervention), participants will receive a journal to record their daily smoking behaviour. They are asked to keep this journal until test session 3 (6 weeks post-intervention). | |
Secondary | Change in smoking cue-induced cigarette cravings from the pre-intervention baseline to test session 2 | Participants will be asked to complete craving and urge to smoke questionnaires at several time points throughout the study sessions | Multiple times points during the baseline, intervention and test sessions at 24 hours, 2 weeks and 6 weeks post-intervention. | |
Secondary | Change in smoking cue-induced cigarette cravings from the pre-intervention baseline to test session 3 | Participants will be asked to complete craving and urge to smoke questionnaires at several time points throughout the study sessions | Multiple times points during the baseline, intervention and test sessions at 24 hours, 2 weeks and 6 weeks post-intervention. | |
Secondary | Change in smoking cue-induced heart rate responses from the pre-intervention baseline to test session 2 | Participants' heart rate will be measured through the use of a polar belt at several time points during the study sessions | Multiple time points during the baseline, intervention and test sessions at 24 hours, 2 weeks and 6 weeks post-intervention | |
Secondary | Change in smoking cue-induced heart rate responses from the pre-intervention baseline to test session 3 | Participants' heart rate will be measured through the use of a polar belt at several time points during the study sessions | Multiple time points during the baseline, intervention and test sessions at 24 hours, 2 weeks and 6 weeks post-intervention | |
Secondary | Change in smoking cue-induced skin conductance responses from the pre-intervention baseline to test session 2 | Participants' skin conductance will be measured through the use of electrodes on their index and middle fingers at several time points during the study sessions | Multiple time points during the baseline, intervention and test sessions at 24 hours, 2 weeks and 6 weeks post-intervention | |
Secondary | Change in smoking cue-induced skin conductance responses from the pre-intervention baseline to test session 3 | Participants' skin conductance will be measured through the use of electrodes on their index and middle fingers at several time points during the study sessions | Multiple time points during the baseline, intervention and test sessions at 24 hours, 2 weeks and 6 weeks post-intervention | |
Secondary | Change in tobacco and other substance use patterns from the pre-COVID-19 baseline to during COVID-19 | Participants will be asked to report the quantity of cigarettes and/or other substances they have consumed recently | Multiple time points at baseline (before the pandemic), at the start of the pandemic, and during the pandemic | |
Secondary | Change in tobacco and other substance use patterns from the pre-COVID-19 baseline to post-COVID-19 | Participants will be asked to report the quantity of cigarettes and/or other substances they have consumed recently | At baseline (before the pandemic) and through study completion, an average of 1 year | |
Secondary | Change in tobacco and other substance use patterns during the COVID-19 pandemic to post-COVID-19 | Participants will be asked to report the quantity of cigarettes and/or other substances they have consumed recently | Multiple time points during the pandemic and through study completion, an average of 1 year |
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