Outcome
| Type |
Measure |
Description |
Time frame |
Safety issue |
| Primary |
Aggregate behavioral economic demand across all participants under the proposed regulatory environments |
Participants will complete trials of the Experimental Tobacco Marketplace wherein the price of a target commodity will be increased. Nonlinear mixed effects modeling will be used to fit a curve to estimate the number of products purchased at each price and the analysis will result in an measure of overall price sensitivity under each of the regulatory conditions. |
Assessed at study week 0 and at study week 9 |
|
| Primary |
Aggregate behavioral economic substitution across all participants under the proposed regulatory environments |
Participants will complete trials of the Experimental Tobacco Marketplace wherein the price of alternative products will be fixed across trials and their usual product will change price. Mixed effects modeling will be used to fit a curve to estimate the slopes and intercepts of these alternative products, revealing the degree to which participants will choose to purchase each alternative product as the price of the participant's usual product increases. |
Assessed at study week 0 and at study week 9 |
|
| Secondary |
Timeline Follow-Back (TLFB): Average of marijuana and nicotine use quantity |
Self-reported marijuana and nicotine product use separated by product type and flavor for the past 60 days. |
Assessed at study week 0 and at study week 9 |
|
| Secondary |
Fagerström Test for Nicotine Dependence (FTND) |
Measure of dependence symptoms, measured on a scale of 0 to 10. A higher score indicates a higher physical dependence on nicotine. |
Assessed at study week 0 and at study week 9 |
|
| Secondary |
Minnesota Nicotine Withdrawal Scale (MNWS) |
Assesses Withdrawal Symptoms. Scored on an ordinal scale ranging from 0 to 3. A higher score indicates increased intensity of symptoms. |
Assessed at study week 0 and at study week 9 |
|
| Secondary |
Hypothetical quantity purchased in purchase tasks |
Measures valuation by assessing hypothetical consumption across a price range and across the range of products used by participants in the past 60 days. |
Assessed at study week 0 and at study week 9 |
|
| Secondary |
Delay Discounting Tasks |
Assesses valuation for future money and nicotine products. |
Assessed at study week 0 and at study week 9 |
|
| Secondary |
Activity Level Questionnaire - Substance Use Version (ALQ-SUV) |
Measures past-month reinforcement from substance-related and substance-free activities, yielding a reinforcement ratio quantifying the proportion of overall reinforcement obtained from nicotine use. The ratio ranges from 0 to 1, with a higher score indicating a greater proportion of reinforcement received from drug-related activities relative to total reinforcement. |
Assessed at study week 0 and at study week 9 |
|
| Secondary |
Breath Carbon Monoxide (CO) |
Breath carbon monoxide readings collected using our app |
Collected twice daily through the 10 week duration of the study |
|
| Secondary |
Salivary Cotinine |
Salivary cotinine collected with rapid test, verified via smartphone app |
Collected with assessment sessions at study weeks 0 and 9, as well as twice weekly remotely during interim sampling period |
|
| Secondary |
Self-reported nicotine product use |
The number of tobacco cigarettes, marijuana cigarettes, and other nicotine/tobacco products consumed. Will be collected with our app. |
Collected daily from study week 1 to study week 9 |
|
| Secondary |
Self-reported withdrawal symptom severity |
On a scale from 0 to 9, participants will report their withdrawal symptom severity in our smartphone app. A higher score indicates more severe symptoms. |
Collected daily from study week 1 to study week 9 |
|
| Secondary |
Self-reported nicotine craving intensity |
On a scale from 0 to 9, participants will report their nicotine craving intensity in our smartphone app. A higher score indicates more intense cravings. |
Collected daily from study week 1 to study week 9 |
|
