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Tobacco Smoking clinical trials

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NCT ID: NCT04014322 Recruiting - Tobacco Smoking Clinical Trials

The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment

Start date: December 12, 2020
Phase: N/A
Study type: Interventional

This study aims to establish the feasibility and acceptability of a project designed to investigate the impact of electronic cigarette use on combustible cigarette smoking and smoking-related factors among smokers with psychiatric disorders, a high-risk population, who are not yet ready to quit smoking. All participants will be instructed to switch completely from combustible cigarettes to e-cigarettes for the next 8 weeks. They will be assessed at baseline, 2 weeks, 4 weeks, 8 weeks and 12 weeks.

NCT ID: NCT03495024 Recruiting - Schizophrenia Clinical Trials

Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates

Start date: January 1, 2019
Phase: Phase 4
Study type: Interventional

To test the feasibility of studying effects of smoking cessation with varenicline on antipsychotic drug-induced neurological side effects, we propose a 12 week pilot study of smoking cessation treatment with varenicline in 10 schizophrenia or schizoaffective disorder patients who are actively smoking and have pre-existing TD while receiving stable doses of antipsychotics. Subjects will be followed after a 2 week baseline period to assess changes in smoking status and neurological symptoms using standardized rating scales. The aim is to examine clinically significant effects on antipsychotic-induced neurological side effects that may warrant further investigation.

NCT ID: NCT03347838 Recruiting - Tobacco Smoking Clinical Trials

Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers

Start date: January 30, 2019
Phase: Phase 2
Study type: Interventional

The goal of this clinical research study is to determine whether the PD-1 inhibitor (Programmed cell death protein 1) nivolumab improves premalignant bronchial dysplastic lesions in subjects that are at high risk for the development of lung cancer, including those with a prior smoking history, or history of lung cancer or head and neck cancer. The safety and tolerability of nivolumab will also be studied.

NCT ID: NCT02124525 Recruiting - Inflammation Clinical Trials

N-acetylcysteine for Tobacco Smoking

NACNOS
Start date: February 2013
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the efficacy of N-acetylcysteine (NAC) for smoking cessation in a double blind, randomized, placebo-controlled trial. Simultaneously, the study aims to elucidate the role of inflammatory markers and oxidative stress related to nicotine addiction and the use of NAC, an acetylated precursor of cysteine, a naturally occurring amino acid that has antioxidant actions in its own right, in reducing oxidative stress and inflammation in smokers. It will evaluate the use of NAC in smoking cessation, after 4, 8 and 12 weeks of treatment.

NCT ID: NCT02028962 Recruiting - Tobacco Smoking Clinical Trials

Computer Tailored Program for Smoking Cessation Among Romanian Adults

Start date: October 2013
Phase: N/A
Study type: Interventional

The research aim is the development, implementation and evaluation of the first computer tailored smoking cessation progam for Romanian adult smokers. It will be implemented among smokers from Romania aged 20-60 years. The participants will beneficiate of tailored information received in letters generated by using sophisticated computer algorithms, allowing the creation of highly individualized messages that address each individual's unique needs, motivations and beliefs related to smoking . Program implementation will comprise of : 1. ''diagnosis'' by means of questionnaires at the individual level of characteristics that are relevant for a person's smoking behavior 2. development of the ''message library'' that contains all education messages that may be needed 3. development of an ''algorithm'', a set of decision rules that evaluates the diagnosis, selects and generates messages tailored to the specific needs of the individual user 4. generating of personalized letters for each participant 5. sending of theses personalized letters to the participants. The participants will receive three personalized letters during a period of six months after registration into the program. The effects of the program will be evaluated with a randomized controlled trial which will assess the changes in smoking behaviour as well as smoking related attitudes, self-efficacy and quiting attempts at 6 months after the enrolment into the program. A process evaluation will assess participants' opinion about the program.

NCT ID: NCT01122589 Recruiting - Cigarette Smoking Clinical Trials

Working Inside for Smoking Elimination

WISE
Start date: February 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the extent to which an Intentional Behavioral Intervention will increase tobacco quit rates post release among incarcerated men and women.