T Cell Lymphoma Clinical Trial
Official title:
A Pilot Study of Sorafenib Examining Biomarkers in Refractory or Relapsed T-Cell Lymphoma Patients
This study will be a pilot study of sorafenib 400mg PO twice daily in refractory T-cell lymphomas including peripheral T-cell lymphoma (PTCL), angioimmunoblastic lymphadenopathy (AILD), cutaneous T cell lymphoma (CTCL), anaplastic large cell lymphoma (ALCL) and other transformed T-cell lymphomas with the primary objective of studying the biological effects of the multikinase inhibitor, sorafenib.
Primary objectives:
• To study the biological effects of sorafenib 400mg BID on the mitogen-activated protein
kinase (MAPK) pathway, specifically the inhibition of extracellular signal-regulated kinases
(ERK) phosphorylation, and to correlate with clinical activity in patients with T-cell
lymphoma.
Secondary objectives:
- To observe the clinical activity of sorafenib 400mg BID by determining response rate,
and progression free survival in patients with T-cell lymphoma. Duration of response and
duration of stable disease will also be measured.
- To determine the tolerability of sorafenib in patients with T-cell lymphoma.
Exploratory objectives:
- To observe the effects of sorafenib on T-cell subsets (CD4/CD8 ratio, and Tregs), and
the effects of sorafenib on the monocytoid population.
- To observe the effects of sorafenib on the serum cytokine profile.
- To observe the effects of sorafenib on the T-cell receptor pathway, i.e. Lck, ZAP-70,
and Syk.
- To observe changes in lymph node or skin morphology including tumor cell infiltrate,
vasculature, and the tumor microenvironment in patients treated with sorafenib by
performing serial biopsies of lymph nodes or skin.
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