Finding the Latent Treponema Pallidum

Status Recruiting

Clinical Trial Summary

Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, srum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls.

Clinical Trial Description

Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, serum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls. ;

Study Design

Related Conditions & MeSH terms

Syphilis

Clinical Trial Details

NCT number	NCT03754517
Study type	Observational
Source	Peking Union Medical College Hospital
Contact	Jun Li
Phone	01069151502
Email	lijun35@hotmail.com
Status	Recruiting
Phase
Start date	August 2016
Completion date	December 2019

View Details

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