Surgery Clinical Trial
Official title:
Investigating the Use of Fluorescent Imaging and Methylene Blue to Identify and Prevent Ureteric Injuries During Laparoscopic and Open Colorectal Surgery
The main aim of this project is to assess whether intravenous methylene blue can help
identify the ureters during open and laparoscopic (keyhole) surgery. The ureters are small
tubes that link the kidney to the bladder and, if not properly identified during surgery,
may be damaged.
Methylene blue has been safely given to patients for many years and it is fluorescent. It is
removed by the kidney and will therefore travel through the ureters. Methylene blue shines
brightly (becomes fluorescent) when viewed under red light.
This study aims to compare the ability of methylene blue with white light to identify the
location of the ureters during colorectal surgery. Recruitment will include 50 patients
undergoing colorectal surgery (25 for keyhole/laparoscopic, 25 for open procedures). Each
patient will act as their own control.
To detect the fluorescence, a special fluorescent laparoscope for keyhole surgery will be
utilised, and a wide-field camera will be used for open surgery.
The potential benefits of this procedure are to identify the ureters during surgery and
therefore prevent inadvertent damage to them
It is hoped that near infra-red light emitting from the ureters will be detected. This will
allow the surgeon to determine the anatomy of the ureters during the operation and avoid
inadvertent injury.
Funding source: Nuffield Department of Surgical Sciences, University of Oxford Recruitment
sites: Oxford University Hospitals NHS Trust.
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