Anti-suicidal Effects of Buprenorphine in Opioid Use Disorder

Status Withdrawn

Clinical Trial Summary

The study aims to examine the effect of buprenorphine on suicidal ideation in individuals with opioid use disorder, and to investigate the functional brain activity related to its potential anti-suicidal effect.

Clinical Trial Description

The current opioid epidemic is an urgent public health problem, contributing significantly to the climbing U.S. suicide rates over the past two decades. Although initially rewarding, chronic opioid use leads to tolerance and escalating negative affective states. This may promote suicidal ideation and may further impair decision-making functions leading to suicidal behavior. Buprenorphine, a treatment for opioid use disorder (OUD), has promise in reducing suicidal ideation. However, the neural mechanism of its anti-suicidal properties remains unknown. Blocking kappa opioid receptors is one mechanism of buprenorphine hypothesized to reverse the negative emotional sensitivity in OUD and thus may underlie its anti-suicidal effects. In this morphine-controlled study, we will examine the effect of buprenorphine on the functional activity of brain regions involved in negative emotional reactivity and investigate whether this effect is associated with its anti-suicidal properties. Buprenorphine has a different mechanism of action than currently available antidepressants and anti-suicidal medications. Understanding this mechanism can help refine its use in this context. Success will guide a future larger study to elucidate molecular mechanisms underlying anti-suicidal properties of buprenorphine. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04234516
Study type	Interventional
Source	New York State Psychiatric Institute
Contact
Status	Withdrawn
Phase	Phase 4
Start date	January 20, 2020
Completion date	June 10, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05334381` - Navigating Mental Health Treatment for Black Youth	N/A
Recruiting	`NCT04653337` - Neuroimaging Guided and Robot-assisted rTMS for Suicidal Ideation of Depression	Phase 2
Terminated	`NCT04254809` - Evaluation of a Computerized Intervention for Learning to Re-Evaluate Suicidal Thoughts	N/A
Recruiting	`NCT05848089` - Real-time Intervention for Suicide Risk Reduction	N/A
Recruiting	`NCT06322199` - Differences Between Suicide Attempters and Suicide Ideators. Influence of the Brief Therapy Attempted Suicide Short Intervention Program (ASSIP) on Neuropsychological Correlates and Psychological Process Factors - Project 3
Recruiting	`NCT05280756` - Home-based tDCS for Prevention of Suicidal Ideation	N/A
Completed	`NCT01944293` - Ketamine for Suicidality in Bipolar Depression	Phase 1/Phase 2
Completed	`NCT02021344` - Mental Health First Aid for College Students	N/A
Not yet recruiting	`NCT04686162` - Bae: A Smartphone Application for a Better Following Adolescents at Risk of Suicidal Behavior: Study of Acceptability and Preliminary Results of Efficacy	N/A
Recruiting	`NCT05377177` - Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI	N/A
Completed	`NCT05580757` - Pharmacists as Gate Keepers in Suicide Prevention: Needs of Pharmacists
Recruiting	`NCT05925322` - Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality	N/A
Not yet recruiting	`NCT05427734` - Treating Drivers of Suicide Using Jaspr Health	N/A
Recruiting	`NCT04112368` - Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach	Phase 4
Completed	`NCT04026308` - Written vs Electronic Safety Planning Study	N/A
Recruiting	`NCT05537376` - A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious Mental Illness	N/A
Not yet recruiting	`NCT06019650` - Culturally Adapted Suicide Prevention Intervention for Older Adults	N/A
Not yet recruiting	`NCT05860257` - Transforming Adolescent Mental Health Through Accessible, Scalable, Technology-supported Small-group Instruction	N/A
Recruiting	`NCT05485701` - Perinatal Mental Health Study (PMHS) India
Recruiting	`NCT05555927` - Adjunctive Duration-doubled tDCS for the Treatment of Depressive Patients With Suicidal Ideation	N/A