Substance Use Disorders Clinical Trial
Official title:
Non-Invasive Brain Stimulation and Substance Use
NCT number | NCT03122587 |
Other study ID # | 16-2342 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | May 15, 2017 |
Est. completion date | February 1, 2019 |
Verified date | July 2019 |
Source | University of North Carolina, Chapel Hill |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The will investigate the feasibility and effectiveness and initial efficacy of non-invasive transcranial alternating current stimulation (tACS) on distress tolerance and inhibitory control among treatment seeking substance users.
Status | Completed |
Enrollment | 38 |
Est. completion date | February 1, 2019 |
Est. primary completion date | February 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 55 Years |
Eligibility |
Inclusion Criteria: - Current Diagnostic and Statistical Manual of Mental Disorders (DSM-V) Substance Use Disorder - Current smoker - Abstinent from all substances (except nicotine) for at least the past 2 weeks Exclusion Criteria: - Current use of antiepileptic drugs and/or benzodiazepines - Less than 6 months since an electroconvulsive therapy (ECT) session - Current DSM-V Psychotic Disorder - Pregnancy and/or nursing - Ongoing or history of traumatic brain injury (TBI), reoccurring seizures, stroke, or brain tumors - Medical or neurological illness - Brain devices and/or implants |
Country | Name | City | State |
---|---|---|---|
United States | Southlight Healthcare | Raleigh | North Carolina |
Lead Sponsor | Collaborator |
---|---|
University of North Carolina, Chapel Hill |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in Distress Tolerance (Mean Latency to Quit the PASAT-C) | The Computerized Paced Auditory Serial Addition Task (PASAT-C) is a psychological distress-inducing task. Numbers are presented sequentially on a computer screen and participants are asked to add the currently presented number to the previously presented number before the next number is presented. Participants select the answer using a computer mouse on a number pad displayed on the computer screen below the presented numbers. The speed of the number presentations is individually titrated in order to account for some individual differences in cognitive capacity, but not to secure equal performance among individuals. Incorrect or delayed responses are met with an aversive explosion sound. Distress tolerance is the latency to task termination (i.e., time until quit in minutes). | From Session 1 to Session 2, up to 6 days | |
Primary | Change in Inhibitory Control (Mean D-prime on the Go/No-Go) | During the computerized Go/No-Go task, participants view a serial stream of pictures and are instructed to continuously press a button on the computer keyboard, but inhibit responses when stimuli are presented consecutively. Inhibitory control will be calculated as d-prime [z(hit rate) - z(false alarm rate)]. Each z-score of 0 is equal to the mean of the reference population, with a standard deviation of 1. Positive d-prime values indicate more inhibitory control, and negative values indicate less inhibitory control. | From Session 1 to Session 2, up to 6 days |
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