Substance-Related Disorders Clinical Trial
Official title:
LAAM With Behavioral Treatment for Opioid/Cocaine Abuse
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained. Thus, this study proposes to examine the clinical efficacy of low- and high-dose LAAM maintenance on opioid and cocaine use in opioid-dependent cocaine abusers. In addition, since contingency management procedures have demonstrated some success in decreasing cocaine use in cocaine-abusing individuals, this study also proposes to examine the clinical efficacy of the presence or absence of contingency management procedures targeting illicit drug use.
One hundred forty male and female opioid-dependent cocaine abusers will be stratified by sex
and randomly assigned to one of four treatment groups according to a 2 x 2 experimental
design: low-dose LAAM (99 mg/wk) with adjunct contingency management procedures; low-dose
LAAM (99 mg/wk) without adjunct contingency management procedures; high-dose LAAM (330
mg/wk) with adjunct contingency management procedures; and high-dose LAAM (330 mg/wk)
without adjunct contingency management procedures. The duration of the study will be 24
weeks, with LAAM being administered on a thrice-weekly (MWF) basis.
Subjects are inducted onto LAAM during weeks 1-3 and then maintained on their assigned
maintenance dose (99 mg/wk or 330 mg/wk) through week 24. During maintenance, the Friday
dose will be 1.3 times greater than the Monday and Wednesday dose. At the conclusion of the
study, subjects undergo detoxification from LAAM over a 4-week period. For those in the
contingency management procedure group, each drug-free urine submitted will result in a
voucher worth a certain monetary value that increases for consecutively drug-free urines
(weeks 1-12) or a monetary voucher with a fixed value (weeks 13-24). Subjects not assigned
to the contingency management procedure will receive monetary vouchers (weeks 1-24)
according to a yoked-control schedule (that is, not contingent upon illicit drug
abstinence). Vouchers can be exchanged for mutually agreed upon goods and services at any
time during the study. Outcome measures will include: 1) treatment retention, 2) illicit
drug use, 3) self-reported adverse and opioid withdrawal symptoms, and 4) psychosocial
functioning. Follow-up interviews at nine months and/or one year post-study entry will be
conducted to determine status post-treatment. Prognostic factors (i.e., sex, post-traumatic
stress disorder, and depression), will also be examined in relation to treatment outcome and
post-treatment status.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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