Effects of Alcohol History on Effects of Nitrous Oxide - 9

Substance-Related Disorders Clinical Trial

Official title:

Effects of Alcohol History on Effects of Nitrous Oxide

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00000257
• Other study ID #: NIDA-08391-9
• Secondary ID: R01DA008391R01-0
• Status: Completed
• Phase: N/A
• First received: September 20, 1999
• Last updated: May 26, 2015
• Start date: September 1995
• Est. completion date: April 1997

Study information

• Verified date: May 2015
• Source: University of Chicago
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: April 1997
• Est. primary completion date: April 1997
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 37 Years
• Eligibility: Please contact site for information.

Study Design

Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

• Alcohol-Related Disorders
• Disease
• Opioid-Related Disorders
• Substance-Related Disorders

Intervention

Drug:
• 0% N2O and 10% N2O

• 0% N2O and 20% N2O

• 0% N2O and 30% N2O

• 0% N2O and 40% N2O

Locations

Country	Name	City	State
United States	University of Chicago, Anesthesia & Critical Care	Chicago	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
University of Chicago	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP. The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Apr 14;45(1-2):63-70. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Choice of nitrous oxide vs placebo	Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject & the technician administering the inhalant were blinded. Testing was done at each dose.	After 30 min inhalation each of N2O and placebo	No