Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8

Substance-Related Disorders Clinical Trial

Official title:

Reinforcing Effects of Brief Exposures to Nitrous Oxide

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00000256
• Other study ID #: NIDA-08391-8
• Secondary ID: R01DA008391R01-0
• Status: Completed
• Phase: N/A
• First received: September 20, 1999
• Last updated: May 26, 2015
• Start date: August 1995
• Est. completion date: November 1996

Study information

• Verified date: May 2015
• Source: University of Chicago
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine reinforcing effects of brief exposures to nitrous oxide in healthy volunteers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: November 1996
• Est. primary completion date: November 1996
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 22 Years to 34 Years
• Eligibility: Please contact site for information.

Study Design

Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

• Disease
• Opioid-Related Disorders
• Substance-Related Disorders

Intervention

Drug:
• 20% N2O

• 40% N2O

• 60% N2O

• 80% N2O

Locations

Country	Name	City	State
United States	University of Chicago, Anesthesia & Critical Care	Chicago	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
University of Chicago	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Zacny JP, Klafta JM, Coalson DW, Marks S, Young CJ, Klock PA, Toledano AY, Jordan N, Apfelbaum JL. The reinforcing effects of brief exposures to nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1996 Nov;42(3):197-200. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Choice of nitrous oxide vs placebo	Subjects underwent 4 sessions consisting of 2 sample tests (inhaling placebo and inhaling varying doses of N2O), then choosing which inhalant they wanted for a choice test. The subject & the technician administering the inhalant were blinded. During each intervention and each session, subjects underwent psychomotor testing.	After 1.5 min of inhalation each of nitrous oxide then placebo	No