Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4

Substance-Related Disorders Clinical Trial

Official title:

Lack of Acute Tolerance Development to Effects of Nitrous Oxide

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00000252
• Other study ID #: NIDA-08391-4
• Secondary ID: R01DA008391R01-0
• Status: Completed
• Phase: Phase 2
• First received: September 20, 1999
• Last updated: May 26, 2015
• Start date: June 1994
• Est. completion date: June 1996

Study information

• Verified date: May 2015
• Source: University of Chicago
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: June 1996
• Est. primary completion date: June 1996
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 29 Years
• Eligibility: Please contact site for information.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Disease
• Opioid-Related Disorders
• Substance-Related Disorders

Intervention

Drug:
• 0% N2O

• 10% N2O

• 20% N2O

• 30% N2O

• 40% N2O

Locations

Country	Name	City	State
United States	University of Chicago, Anesthesia & Critical Care	Chicago	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
University of Chicago	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JL. Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav. 1996 Jun;54(2):501-8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Psychomotor performance	Subjects will undergo psychomotor testing during 120 min inhalation session of each intervention	During inhalation	No
Primary	Cognitive performance	Subjects will under cognitive testing during 120 minute inhalation session of each intervention	During inhalation	No