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NCT00000249 Clinical Trial

Effects of Subanesthetic Concentrations of Nitrous Oxide - 1

Substance-Related Disorders Clinical Trial

Official title:
Effects of Subanesthetic Concentrations of Nitrous Oxide

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00000249
Other study ID # NIDA-08391-1
Secondary ID R01DA008391R01-0
Status Completed
Phase Phase 2
First received September 20, 1999
Last updated May 26, 2015
Start date September 1993
Est. completion date June 1995

Study information
Verified date May 2015
Source University of Chicago
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.

Recruitment information / eligibility
Status Completed
Enrollment 10
Est. completion date June 1995
Est. primary completion date June 1995
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 21 Years to 37 Years
Eligibility Please contact site for information.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• 20% N2O
20% inhaled N2O
• 30% N2O
30% inhaled N2O
• 40% N2O
40% inhaled N2O

Locations
Country Name City State
United States University of Chicago, Anesthesia & Critical Care Chicago Illinois

Sponsors (2)
Lead Sponsor Collaborator
University of Chicago National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Pharmocol Biochem and Behavior 1995, 51( 2): 323-329

Outcome
Type Measure Description Time frame Safety issue
Primary Pain intensity Subjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes during cold test at 10 min & 30 min of inhalation No
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