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Subarachnoid Hemorrhage clinical trials

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NCT ID: NCT05686265 Terminated - Clinical trials for Subarachnoid Hemorrhage, Aneurysmal

Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage

NOX2
Start date: May 11, 2023
Phase:
Study type: Observational

Aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, which is in part due to the development of secondary brain injury. The mechanisms behind this remain incompletely understood, but oxidative/nitrosative stress and disturbances in vasoregulatory mechanisms are believed to be involved. The present study aims to characterise the transcerebral exchange of oxidative/nitrosative stress markers and nitric oxide metabolites during the early phase after SAH compared to healthy volunteers, including the influence of induced changes in arteriel oxygen tension.

NCT ID: NCT05259514 Terminated - Clinical trials for Aneurysmal Subarachnoid Haemorrhage

CytoSorb SAH Trial

Start date: January 31, 2022
Phase: N/A
Study type: Interventional

In aSAH high levels of IL-6 (a pro-inflammatory cytokine) in the cerebrospinal fluid, as well as systemically have been linked to the severity grade and the occurrence of vasospasm and delayed cerebral ischemia caused by vasospasm as well as worse outcome independent of severity grade at time of admission and age. Increased levels of IL-6 increase the probability of unfavourable outcome, as well as the occurrence of delayed ischemic neurological deficit. CytoSorb is an available, and certified medical device intended for use in conditions where elevated levels of cytokines such as IL-6 exist. Its clinical effect lies in the reduction of levels of pro-inflammatory mediators and thereby improving organ function as well as improving hemodynamic stability within hours of treatment initiation. Currently it is primarily used for the treatment of patients with confirmed or imminent respiratory failure who have either an acute lung injury, or acute respiratory distress syndrome, or a severe disease incl. respiratory failure, septic shock, and or multiple organ dysfunction/failure. Until now, effective IL-6 removal in patients suffering from aSAH has not been possible in human and thus has not yet been evaluated. The purpose of this study is to see whether removal of IL-6 in patients with aSAH using CytoSorb is possible, and whether this alters the clinical course. The overall goal of this study is to investigate whether a treatment with CytoSorb removes Interleukin 6 in patients with aSAH, and whether the treatment with CytoSorb alters the clinical course.

NCT ID: NCT04148105 Terminated - Clinical trials for Aneurysmal Subarachnoid Hemorrhage

Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)

Start date: November 1, 2019
Phase: Phase 4
Study type: Interventional

The investigators seek to demonstrate that the combined use of cilostazol and nimodipine will significantly decrease the rate of delayed cerebral infarction and cerebral vasospasm after cerebrovascular intervention when compared to nimodipine alone.

NCT ID: NCT03471702 Terminated - Clinical trials for Subarachnoid Hemorrhage

A Secondary Study Evaluating Aqueduct's Smart External Drain (SED)

Start date: February 28, 2018
Phase: N/A
Study type: Interventional

Aqueduct's Smart External Drain (SED) will be compared to the current gold standard for temporary CSF management in a hospital setting. - Evaluate the number of subjects requiring to be switched to a standard of care EVD - Evaluate subject transport while on the SED - Evaluate SED system control from initiation of SED through discharge of external drain system

NCT ID: NCT03032471 Terminated - Stroke Clinical Trials

Swiss SOS MoCA - DCI Study

Start date: July 20, 2017
Phase:
Study type: Observational

The primary objective of this multicenter observational study is to determine the effect size of the relationship between DCI and neuropsychological impairment 14-28 days and 3 months after aSAH. Secondary objectives are the feasibility to administer and the validity of the MoCA in an intensive care unit setting, as well as the test/retest reliability of the MoCA in patients with acute brain damage in absence of aSAH.

NCT ID: NCT02996266 Terminated - Ischemic Stroke Clinical Trials

Impact of Fever Prevention in Brain Injured Patients

INTREPID
Start date: January 2017
Phase: N/A
Study type: Interventional

This study will assess the impact of fever prevention on fever burden and short- and long-term neurologic outcomes in brain injured patients. Half of the subjects will undergo fever prevention using a targeted temperature management system and half of the subjects will be treated for fever should it develop.

NCT ID: NCT02907879 Terminated - Clinical trials for Subarachnoid Hemorrhage

Contrast Enhanced Ultrasound Imaging for Cerebral Perfusion Measurement in Cerebral Vasospasm After SAH

Start date: July 2013
Phase:
Study type: Observational

The objective of the study is to assess brain tissue perfusion by ultrasound perfusion imaging. Specifically - to diagnose brain tissue hypoperfusion due to CVS with contrast enhanced UPI and to assess specificity and sensitivity, and predictive values for detection of brain tissue hypoperfusion leading to infarction - to test whether treatment-effects by induced hypertension, balloon-dilatation, or intra-arterial nimodipine infusion can be detected and quantified by UPI

NCT ID: NCT02893826 Terminated - Clinical trials for Subarachnoid Hemorrhage, Aneurysmal

Safety/Pharmacokinetic Study Comparing Intracisternal EG-1962 to Standard of Care Enteral Nimodipine in Adults With aSAH

Start date: September 2016
Phase: Phase 1
Study type: Interventional

Safety and Pharmacokinetic study comparing intracisternal EG-1962 to enternal nimopidine in the treatment of aneurysmal subarachnoid hemorrhage.

NCT ID: NCT02864940 Terminated - Clinical trials for Subarachnoid Hemorrhage

Memory Training in Aneurysmal Subarachnoid Hemorrhage Patients

MASH
Start date: June 2016
Phase: N/A
Study type: Interventional

The study aim is to determine if periodic online cognitive exercises (Lumosity) improve memory function in ruptured cerebral aneurysm patients with disabling baseline memory deficits within the first 24 months after rupture. Half of the subjects will be randomized to use Lumosity-designed online cognitive exercises and half will serve as an active control group performing online crossword puzzles.

NCT ID: NCT02790632 Terminated - Clinical trials for Subarachnoid Hemorrhage, Aneurysmal

Study of EG-1962 Compared to Standard of Care Oral Nimodipine in Adults With Aneurysmal Subarachnoid Hemorrhage

NEWTON2
Start date: July 2016
Phase: Phase 3
Study type: Interventional

This study compares EG-1962 to enteral nimodipine in the treatment of aneurysmal subarachnoid hemorrhage.