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The Modulatory Effect of Low-intensity Priming Intermittent Theta Burst Stimulation on Motor Cortex Poststroke: a Concurrent TMS-EEG Study

Stroke Clinical Trial

Official title:
The Modulatory Effect of Low-intensity Priming Intermittent Theta Burst Stimulation on Motor Cortex Poststroke: a Concurrent TMS-EEG Study

Clinical Trial Summary

Background: The optimization of the intensity of priming theta burst stimulation increases the probability of success in a randomized controlled trial. We hypothesize that priming intermittent theta burst stimulation (iTBS) with a low-intensity continuous theta burst stimulation (cTBS) will yield superior effects than our original priming protocol in healthy adults and patients after stroke. Methods: 15 healthy adults and 15 stroke patients will undergo three separate experimental conditions: a low-intensity priming stimulation (55% resting motor threshold [RMT] cTBS+70% RMT iTBS), a conventional-intensity priming stimulation (70% RMT cTBS+70% RMT iTBS), and a nonpriming control. The alterations in cortical excitation/inhibition and its impacts on motor behaviors will be evaluated following stimulation. Significance: The findings will inform future clinical trials investigating the optimized priming iTBS in promoting poststroke recovery.

Clinical Trial Description

Background: The optimization of the intensity of priming theta burst stimulation increases the probability of success in a randomized controlled trial. We hypothesize that priming intermittent theta burst stimulation (iTBS) with a low-intensity continuous theta burst stimulation (cTBS) will yield superior effects than our original priming protocol in healthy adults and patients after stroke. Methods: 15 healthy adults and 15 stroke patients will undergo three separate experimental conditions: a low-intensity priming stimulation (55% resting motor threshold [RMT] cTBS+70% RMT iTBS), a conventional-intensity priming stimulation (70% RMT cTBS+70% RMT iTBS), and a nonpriming control. The alterations in cortical excitation/inhibition and its impacts on motor behaviors will be evaluated following stimulation. Significance: The findings will inform future clinical trials investigating the optimized priming iTBS in promoting poststroke recovery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06241508
Study type Interventional
Source The Hong Kong Polytechnic University
Contact Jack Zhang, PhD
Phone 27666696
Email jack-jq.zhang@connect.polyu.hk
Status Not yet recruiting
Phase N/A
Start date February 15, 2024
Completion date June 30, 2025
View Details
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