Stroke Clinical Trial
Official title:
Effects of Verb Network Strengthening Treatment (VNeST) Provided Via Telerehabilitation on Word Finding in Individuals With Post-stroke Aphasia: a Group Study.
Despite evidence showing that speech and language intervention may improve language and communication abilities in people with acquired language disorders (aphasia), there is still need for evidence for which types of therapy are effective. Further, to improve accessibility of care, there is increasing need for evidence of intervention effects when therapy is provided online, via telerehabilitation. Therefore, the project aims at evaluating the effects of telerehabilitation with a specific speech-language therapy intervention for improving word-finding in individuals with aphasia due to stroke. The intervention Verb Network Strengthening Treatment (VNeST) trains word finding at sentence level, and the treatment effect is expected to generalize to the production of connected speech.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | December 2026 |
Est. primary completion date | December 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility | Inclusion Criteria: - Aphasia and subjective experience of word finding difficulties - Diagnosed left hemisphere stroke at least six months post-onset - With correction, sufficient hearing and vision to be able to participate in training and assessment. - Sufficient stamina to be able to participate in training and assessment. - Swedish as one of the first languages. Exclusion Criteria: - Other known neurological conditions - Untreated epilepsy - Severely impaired comprehension - Moderate-severe dysarthria or apraxia of speech which may interfere with assessment. - Speech-language treatment targeting specifically word finding during participation in the study. - Participation in other studies/clinical treatment using Verb Network Strengthening Treatment (VNeST) during three months prior to the study. - Active substance dependence |
Country | Name | City | State |
---|---|---|---|
Sweden | University of Gothenburg and Västra Götalandsregionen | Gothenburg, | Västra Götaland |
Lead Sponsor | Collaborator |
---|---|
Vastra Gotaland Region | The Swedish Research Council |
Sweden,
Brady MC, Kelly H, Godwin J, Enderby P, Campbell P. Speech and language therapy for aphasia following stroke. Cochrane Database Syst Rev. 2016 Jun 1;2016(6):CD000425. doi: 10.1002/14651858.CD000425.pub4. — View Citation
Edmonds LA, Babb M. Effect of verb network strengthening treatment in moderate-to-severe aphasia. Am J Speech Lang Pathol. 2011 May;20(2):131-45. doi: 10.1044/1058-0360(2011/10-0036). Epub 2011 Mar 8. — View Citation
Edmonds LA, Mammino K, Ojeda J. Effect of Verb Network Strengthening Treatment (VNeST) in persons with aphasia: extension and replication of previous findings. Am J Speech Lang Pathol. 2014 May;23(2):S312-29. doi: 10.1044/2014_AJSLP-13-0098. — View Citation
Edmonds LA, Nadeau SE, Kiran S. Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval of Content Words in Sentences in Persons with Aphasia. Aphasiology. 2009 Mar 1;23(3):402-424. doi: 10.1080/02687030802291339. — View Citation
Goodglass, H., Kaplan, E., & Weintraub, S. (1983). Boston naming test. Philadelphia, PA: Lea & Febiger.
Hilari K, Lamping DL, Smith SC, Northcott S, Lamb A, Marshall J. Psychometric properties of the Stroke and Aphasia Quality of Life Scale (SAQOL-39) in a generic stroke population. Clin Rehabil. 2009 Jun;23(6):544-57. doi: 10.1177/0269215508101729. Epub 2009 May 15. — View Citation
Kiran S, Thompson CK. The role of semantic complexity in treatment of naming deficits: training semantic categories in fluent aphasia by controlling exemplar typicality. J Speech Lang Hear Res. 2003 Aug;46(4):773-87. doi: 10.1044/1092-4388(2003/061). — View Citation
Kristensson J, Saldert C, Ostberg P, Smith SR, Ake S, Longoni F. Naming vs. non-naming treatment in aphasia in a group setting-A randomized controlled trial. J Commun Disord. 2022 May-Jun;97:106215. doi: 10.1016/j.jcomdis.2022.106215. Epub 2022 Mar 17. — View Citation
Long A, Hesketh A, Bowen A; ACT NoW Research Study. Communication outcome after stroke: a new measure of the carer's perspective. Clin Rehabil. 2009 Sep;23(9):846-56. doi: 10.1177/0269215509336055. Epub 2009 May 29. Erratum In: Clin Rehabil. 2010 Apr;24(4):383. — View Citation
Long A, Hesketh A, Paszek G, Booth M, Bowen A. Development of a reliable self-report outcome measure for pragmatic trials of communication therapy following stroke: the Communication Outcome after Stroke (COAST) scale. Clin Rehabil. 2008 Dec;22(12):1083-94. doi: 10.1177/0269215508090091. — View Citation
Masterson, J., & Druks, J. (1998). Description of a set of 164 nounsand 102 verbs matched for printed word frequency, familiarityand age-of-acquisition. Journal of Neurolinguistics, 11(4), 331-354
Nicholas LE, Brookshire RH. A system for quantifying the informativeness and efficiency of the connected speech of adults with aphasia. J Speech Hear Res. 1993 Apr;36(2):338-50. doi: 10.1044/jshr.3602.338. — View Citation
Torinsson, M., Saldert, C., Rödseth Smith, S., Kristensson, J., & Longoni, F. (2023). Telerehabilitation with Verb Network Strengthening Treatment (VNeST) in two persons with mild-to-moderate and moderate-to-severe aphasia: A single-case experimental design study. Submitted manuscript.
Webster J, Whitworth A. Treating verbs in aphasia: exploring the impact of therapy at the single word and sentence levels. Int J Lang Commun Disord. 2012 Nov-Dec;47(6):619-36. doi: 10.1111/j.1460-6984.2012.00174.x. Epub 2012 Jul 18. — View Citation
* Note: There are 14 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from baseline in naming ability of trained items at week 10. | Naming of ten trained phrases including an agent (subject), verb and a patient (object) with moving picture stimuli. Possible score ranges from 0 (worst) to 40 (best). | Baseline, 10 weeks | |
Primary | Change from baseline in naming ability of trained items at week 14. | Naming of ten trained phrases including an agent (subject), verb and a patient (object) with moving picture stimuli. Possible score ranges from 0 (worst) to 40 (best). | Baseline, 14 weeks | |
Secondary | Change from baseline in naming ability of untrained items at week 10. | A measure of generalization of treatment effects to naming of ten untrained phrases including an agent (subject), verb and a patient (object) with moving picture stimuli. Possible score ranges from 0 (worst) to 40 (best). | Baseline, 10 weeks. | |
Secondary | Change from baseline in naming ability of untrained items at week 14. | A measure of generalization of treatment effects to naming of ten untrained phrases including an agent (subject), verb and a patient (object) with moving picture stimuli. Possible score ranges from 0 (worst) to 40 (best). | Baseline, 14 weeks. | |
Secondary | Change from baseline in confrontation naming of single words (objects and actions) at week 10. | The Object & Action Naming Battery (Masterson & Druks, 1998) is a measure of change in ability to name eighty pictures consisting of simple black and white drawings of objects and actions. Possible score range: 0 (worst) to 80 (best). | Baseline, 10 weeks. | |
Secondary | Change from baseline in confrontation naming of single words (objects and actions) at week 14. | The Object & Action Naming Battery (Masterson & Druks, 1998) is a measure of change in ability to name eighty pictures consisting of simple black and white drawings of objects and actions. Possible score range: 0 (worst) to 80 (best). | Baseline, 14 weeks. | |
Secondary | Change from baseline in confrontation naming of single words (objects) at week 10. | The Boston naming test (Goodglass et al, 1983) is a measure of change in ability to name sixty simple black and white drawings of objects. Possible score range 0 (worst) to 60 (best). | Baseline, 10 weeks | |
Secondary | Change from baseline in confrontation naming of single words (objects) at week 14. | The Boston naming test (Goodglass et al, 1983) is a measure of change in ability to name sixty simple black and white drawings of objects. Possible score range 0 (worst) to 60 (best). | Baseline, 14weeks | |
Secondary | Change from baseline in connected speech at week 10. | Connected speech tasks (Nicholas & Brookshire, 1993) measures of change in ability to retrieve words in a picture description tasks and a procedural information task. The speech produced in each task is analysed and number of words and adequate information units produced is calculated and related to time taken to produce the information. Higher numbers indicate better results. | Baseline, 10 weeks | |
Secondary | Change from baseline in connected speech at week 14. | Connected speech tasks (Nicholas & Brookshire, 1993) measures of change in ability to retrieve words in a picture description tasks and a procedural information task. The speech produced in each task is analysed and number of words and adequate information units produced is calculated and related to time taken to produce the information. Higher numbers indicate better results. | Baseline, 14 weeks | |
Secondary | Change from baseline in self-perceived functional communication abilities at week 10 | Communication Outcomes After Stroke scale (COAST, Long et al. 2008) is a validated measure of participants' perception of their communicative ability. Possible score range is 0 (worse) to 80 (best). | Baseline, 10 weeks | |
Secondary | Change from baseline in self-perceived functional communication abilities at week 14 | Communication Outcomes After Stroke scale (COAST, Long et al. 2008) is a validated measure of participants' perception of their communicative ability. Possible score range is 0 (worse) to 80 (best). | Baseline, 14 weeks | |
Secondary | Change from baseline in proxy's reports of participants' communicative ability at week 10. | The Carer Communication Outcomes After Stroke scale (carer COAST, Long et al. 2009). is a validated measure of proxy's perception of the participants' communicative ability. Possible score range is 0 (worse) to 80 (best). | Baseline, 10 weeks | |
Secondary | Change from baseline in proxy's reports of participants' communicative ability at week 14. | The Carer Communication Outcomes After Stroke scale (carer COAST, Long et al. 2009). is a validated measure of proxy's perception of the participants' communicative ability. Possible score range is 0 (worse) to 80 (best). | Baseline, 14 weeks | |
Secondary | Change from baseline in self reported quality of life at week 10. | The Stroke Aphasia Quality of Life (SAQOL-39, Hilari et al 2009) is a validated measure of change in participant reported health related quality of life in a questionnaire with 39 items where participants evaluate of their everyday functioning in three domains: physical, psychosocial and communication. Scoring in each domain will be summarized and averaged and presented separately as well as in a compound averaged score. Possible score range is 1 (worse) to 5 (best). | Baseline, 10 weeks | |
Secondary | Change from baseline in self reported quality of life at week 14. | The Stroke Aphasia Quality of Life (SAQOL-39, Hilari et al 2009) is a validated measure of change in participant reported health related quality of life in a questionnaire with 39 items where participants evaluate of their everyday functioning in three domains: physical, psychosocial and communication. Scoring in each domain will be summarized and averaged and presented separately as well as in a compound averaged score. Possible score range is 1 (worse) to 5 (best). | Baseline, 14 weeks |
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