Stroke Clinical Trial
Official title:
Transcranial Alternating Current Stimulation (tACS) to Enhance Language Abilities
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.
Status | Not yet recruiting |
Enrollment | 120 |
Est. completion date | August 31, 2028 |
Est. primary completion date | August 31, 2028 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria for Persons with Aphasia: 1. Presence of aphasia 2. Suffered a single, left hemisphere stroke 3. Stroke =6 months old (chronic) at the time of enrollment Inclusion Criteria for Healthy Controls: 1. Right-handedness 2. Must be able to understand the nature of the study, and give informed consent Exclusion criteria for Persons with Aphasia: 1. Inability to understand the nature of the study 2. Marked naming impairment 3. Impaired non-verbal, conceptual processing 4. History of significant medical or neurological disorder (other than stroke) 5. History of significant or poorly controlled psychiatric disorders 6. Current abuse of alcohol or drugs, prescription or otherwise 7. Nursing a child, pregnancy, or intent to become pregnant during the study 8. Clinically significant hearing loss 9. Contraindications to tACS 10. Contraindications to MRI Exclusion Criteria for Healthy Controls 1. Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint 2. Any unrelated neurologic or physical condition that impairs communication ability 3. History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit 4. Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations 5. A medically unstable cardiopulmonary or metabolic disorder 6. Terminal illness associated with survival <12 months 7. Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician 8. Current abuse of alcohol or drugs, prescription or otherwise 9. Contraindications to tACS 10. Contraindications to MRI |
Country | Name | City | State |
---|---|---|---|
United States | University of Pennsylvania | Philadelphia | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pennsylvania |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Performance on the Blocked-Cyclic Naming (BCN) Task | The BCN tasks involves naming a set of pictures repeatedly. Sets of pictures come from either the same semantic category (high competition condition; e.g., categorically related: "dog", "cat", "panda") or different semantic categories (low competition condition; e.g., unrelated: dog, eye, crib). | 5-10 minutes after a single session of active (alpha tACS) and sham (fake tACS). |
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