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Immunomodulatory Effects of PCSK9 Inhibition — INSPIRAR  

Stroke Clinical Trial

Official title:
ImmuNomodulatory EffectS of PCSK9 Inhibition: A TaRgeted Molecular Imaging AppRoach

Clinical Trial Summary

Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also have pleiotropic effects on inflammation. The immunomodulatory effects of these medications are relevant to ASCVD risk reduction given that inflammation plays a central role in atherosclerotic plaque formation (atherogenesis) and influences the development of vulnerable plaque morphology. Patients on statins, however, may have residual inflammation contributing to incident ASCVD despite the potent LDL-lowering effects of statins. While new therapies, such as proprotein convertase subtilisin/kexin type 9 (PSCK9) inhibitors, further reduce incident ASCVD and drastically reduce LDL-C below that achieved by statin therapy alone, PCSK9 inhibitors may also have pleiotropic effects on inflammation. Thus, PCSK9 inhibitors may help reduce arterial inflammation to a level closer to that of patients without ASCVD. This study will apply a novel targeted molecular imaging approach, technetium 99m (99mTc)-tilmanocept SPECT/CT, to determine if residual macrophage-specific arterial inflammation is present with statin therapy and the immunomodulatory effects of PSCK9 inhibition. Given the continued high mortality and morbidity attributable to ASCVD, strong imperatives exist to better understand the immunomodulatory effects of lipid lowering therapies and residual inflammatory risk. This understanding, in turn, will inform the development of new ASCVD preventative and treatment strategies as well as elucidate other indications for established therapies.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Arterial Inflammation
  • Arteritis
  • Atherosclerosis
  • Atherosclerotic Cardiovascular Disease
  • Cardiovascular Diseases
  • Carotid Artery Diseases
  • Carotid Atherosclerosis
  • Cerebrovascular Accident
  • Heart Attack
  • Heart Diseases
  • Hypercholesterolemia
  • Hyperlipidemias
  • Inflammation
  • Ischemic Attack, Transient
  • Myocardial Infarction
  • Peripheral Arterial Disease
  • Peripheral Vascular Diseases
  • Stroke
  • Transient Ischemic Attack
  • Vascular Calcification
  • Vascular Disease, Peripheral
  • Vascular Diseases
Clinical Trial Details
NCT number NCT05720156
Study type Observational
Source Massachusetts General Hospital
Contact Mabel Toribio
Phone 617-724-2826
Email mptoribio@mgh.harvard.edu
Status Recruiting
Phase
Start date April 4, 2024
Completion date March 2026
View Details
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