Stroke Clinical Trial
Official title:
Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke
Verified date | May 2024 |
Source | Indiana University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to investigate if a beetroot juice supplement can improve oxygen capacity during walking tasks at a submaximal and maximal effort in people greater than 6 months following stroke.
Status | Completed |
Enrollment | 22 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 89 Years |
Eligibility | Inclusion Criteria: - adults aged 18-89 years - diagnosis of chronic hemiparesis following unilateral stroke (greater than six months) - ability to ambulate at least 0.3 m/s, with or without using an assistive device or bracing below the knee - ability to read and understand English - follow three-step commands Exclusion Criteria: - presence of cerebellar deficits - any other neurological or orthopedic deficits that would limit walking ability - smoking - cannot receive physical therapy for gait-related impairments - uncontrolled metabolic, respiratory, and cardiovascular disease |
Country | Name | City | State |
---|---|---|---|
United States | Rehabilitation Hospital of Indiana | Indianapolis | Indiana |
Lead Sponsor | Collaborator |
---|---|
Indiana University |
United States,
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Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol. 2009 Dec;5(12):865-9. doi: 10.1038/nchembio.260. — View Citation
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Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in gait efficiency during steady state walking | Oxygen Consumption during steady state walking prior to and following placebo or beetroot juice ingestion | Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion | |
Primary | Changes in plasma levels of Nitrate and Nitrite | Blood samples taken prior and following ingestion of either the beetroot juice or placebo supplements. | Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion | |
Secondary | Changes in peak Treadmill Speed | Fastest speed achieved for one minute on the treadmill during the graded treadmill test performed prior to and following placebo or beetroot juice ingestion. | Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion | |
Secondary | Changes in peak oxygen consumption during maximum gait speed | Oxygen Consumption during maximal exertion walking during the graded treadmill test prior to and following placebo or beetroot juice ingestion | Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion. | |
Secondary | Changes in peak heart rate during the graded treadmill test | Peak heart rate during maximal exertion walking on the graded treadmill test prior to and following placebo or beetroot juice ingestion | Measures assessed prior to and following 2-3 hours after beetroot juice or placebo ingestion. |
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