Disconnection and Unilateral Spatial Neglect

Stroke Clinical Trial

— DISCONEGLECT  

Official title:

Neural Basis of Unilateral Spatial Neglect After Stroke: a Retrospective Disconnectome Based Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05268159
• Other study ID #: HLJ_2022_02
• Status: Completed
• Start date: June 1, 2011
• Est. completion date: December 31, 2021

Study information

• Verified date: February 2022
• Source: University Hospital, Lille
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Unilateral spatial Neglect (USN) and other cognitive impairments (including attention, executive functions, memory) have been assessed in routine care at the subacute phase (<6 months). MRI scans have also been done in routine care.

The study aims at linking lesion characteristics, disconnections induced and expression of the different modalities of USN

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: December 31, 2021
• Est. primary completion date: December 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• First hemispheric adult stroke patient

• Non-opposed to inclusion

• Confirmed by MRI

• Assessment of cognitive functions during the subacute phase (3 weeks to 6 months after stroke onset

Exclusion Criteria:

• History of previous stroke or neurological disorders

• Inability to perform cognitive assessment due to severe comprehension, cognitive or psychiatric disorder

• Uncorrected severe loss of visual acuity

• Contra-indications to MRI

Related Conditions & MeSH terms

• Stroke

Intervention

Other:
• Cognitive assessment
Assessment of unilateral spatial neglect, attention, executive functions and memory

Locations

Country	Name	City	State
France	Hop Swynghedauw	Lille

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Lille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessment of peripersonal Unilateral Neglect with the BEN (Batterie d'évaluation de la negligence, Battery of tests for the quantitative assessment of unilateral neglect)		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of personal Unilateral Spatial Neglect with the Fluff Test		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of personal Unilateral Spatial Neglect with the Comb and Razor Test		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of Attention with the Test of Attentional Performance		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of Executive Functions with the Stroop Test		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of Executive Functions with the Trail Making Test		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of Executive Function with Verbal and Categorial Fluency test		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of Executive Functions with the test of commissions		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of verbal Memory with the verbal span task		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of verbal Memory with the Grober and Buschke Task		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of visual Memory with the Doors test		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Assessment of visual Memory with the Rey figure test		One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Secondary	Identification of brain lesions by Anatomical MRI (T1, FLAIR, T2*, Diffusion)		up to 6 months
Secondary	Postural assessment with the PASS		1 month after stroke
Secondary	Postural assessment with the PASS		3 months after stroke
Secondary	Gait assessment (Lindmark score)		1 month after stroke
Secondary	Gait assessment (Lindmark score)		3 months after stroke