Stroke Clinical Trial - Magnesium & Cognition After Stroke

Status Recruiting

Clinical Trial Summary

Cognitive impairments such as memory impairments, word-finding difficulties, compromised orientation and perception are often observed in stroke patients. Low serum-mg-concentrations are associated with cognitive impairments in ischemic stroke patients one month after stroke onset. It is not clear, if cognitive impairments after stroke is caused by the mg-deficiency or by the stroke itself. Until now, no studies investigating the relationship between mg-concentration, stroke severity and cognition during treatment course are available. Thus, this study aimed to investigate the relationship between mg-concentration and cognition of stroke patients.

Clinical Trial Description

Stroke patients admitted to the stroke unit will be included. Initial mg-concentration in serum as well as stroke related measures (National Institutes of Health Stroke Scale, Scandinavian Stroke Scale, modified Rankin Scale) will be ealuated. Moreover, the cognitive abilities of the patient will be assessed within the first three days via the Kölner Neuropsychologische Screening for stroke patients as well as the Mini Mental Status Test. During stroke rehabilitation mg-level, stroke related measures (NIHSS,SSS,MRS) as well as the cognitive tests (MMST,KöpSS) will be re-assed after 4 weeks, 3 month as well as at study end, which is defined as discharge from the clinic (death, transfer to another hospital without return after 4 weeks, discharge to long-term nursing/ home/hospice). Attention-network of stroke patients are measeared if the patient undergo a MRi scan. In this study following questions will be assessed: 1. What is the incidence of cognitive impairments in stroke patients? 1. Are there differences between ischemic and hemorrhagic stroke patients? 2. Are there age and/or gender differences? 2. Are there differences regarding the mg-concentration at admission in comparison to the follow-up (week 4 after admission, 3 month after admission) and between patients with/without cognitive impairments? 3. Is there a correlation between the mg-concentration and the stroke severity? 4. Is there a correlation between the scores of the different cognitive tests (MMST and KöpSS)? 5. Is there an association between the stroke severity, the cognitive impairments (KöpSS) and the neuronal attention network? ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05132517
Study type	Observational
Source	BDH-Klinik Hessisch Oldendorf
Contact	Simone B Schmidt, Dr.
Phone	0049 5152 781 215
Email	si.schmidt@nkho.de
Status	Recruiting
Phase
Start date	October 26, 2022
Completion date	June 30, 2024

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Magnesium and Cognition After Stroke

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms