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Iron Chelation in the Prevention of Secondary Degeneration After Stroke — CHEL-IC  

Stroke Clinical Trial

Official title:
Long-term Iron Chelation in the Prevention of Secondary Remote Degeneration After Stroke

Clinical Trial Summary

Stroke is a major cause of disability over the world. While acute therapies have made huge progresses, the number of survivors leaving with clinical consequences of stroke is increasing. Beyond stroke itself, secondary neurodegeneration of disconnected areas, especially of central hubs such as the substantia nigra or the thalamus, could significantly impact the overall outcome of the patients. Data have identified iron accumulation within the disconnected areas as potentially accelerating neurodegeneration. In this research, the main objective is test whether long-term chelation through Deferiprone (Ferrirpox®, Chiesi) administered daily from 3-to-5 days following stroke to 6 months could avoid iron accumulation as measured with Magnetic resonance imaging (MRI) within disconnected areas (substantia nigra). MRI imaging methods such as the quantification of the transverse relaxation rate R2* provide highly correlated information to the histologically measured iron load

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05111821
Study type Interventional
Source University Hospital, Bordeaux
Contact Thomas TOURDIAS, Pr.
Phone 05 56 79 56 04
Email thomas.tourdias@chu-bordeaux.fr
Status Recruiting
Phase Phase 2
Start date June 8, 2022
Completion date December 8, 2024
View Details
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