Biomarkers to Predict Gain From Therapy in Motor Stroke — GAIN  

Stroke Clinical Trial

Official title: Biomarkers to Predict Gain From Therapy in Motor Stroke

Status Not yet recruiting

Clinical Trial Summary

The aim is to determine predictors of treatment response, i.e gain from rehabilitation training, in post stroke upper limb deficits. The investigators will like to answer the following question: "What is this patient's potential for recovery, given his profile?" The investigators propose to conduct a longitudinal physiopathological study on the stroke patients with motor deficits who entered the rehab center of Pitié Salpêtrière hospital. The investigators will benefit from the organization, which is already in place (clinical asssessments and training) to add MRI, TMS and EEG recordings, as well as genotype analysis before the training offered in the rehabilitation unit. The investigators will repeat these assessments after the training (immeadiately and 6 weeks after).

Clinical Trial Description

The protocol is based on 10 visits. The three main one are V1, V9 and V10. V1, V9 and V10 are the assessments visits with clinical scores, MRI TMS and EEG recordings. These are made before the training (V1), immediately after the 6 weeks of training (V9) and 6 weeks after (V10) V5 is a visit where the investigators will clinically assess the patients at three weeks of the training.

The other visits (V2, V3, V4, V6, V7, V8) consist in recording an EEG while patients are under training each week during six weeks. ;

Related Conditions & MeSH terms

• Biomarker
• Motor Activity
• Stroke

• NCT number: NCT03739892
• Study type: Interventional
• Source: Institut National de la Santé Et de la Recherche Médicale, France
• Contact: Charlotte ROSSO, MD PhD
• Phone: +33142162103
• Email: charlotte.rosso@aphp.fr
• Status: Not yet recruiting
• Phase: N/A
• Start date: November 2018
• Completion date: October 2020