Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke

Stroke Clinical Trial

Official title:

Effects of 8-week Sensory Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03277534
• Other study ID #: 104-2314-B-010-024
• Status: Completed
• Phase: N/A
• First received: September 5, 2017
• Last updated: September 6, 2017
• Start date: August 28, 2013
• Est. completion date: January 4, 2017

Study information

• Verified date: September 2017
• Source: National Yang Ming University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study investigated whether electrical stimulation (ES) prior to a hand function training session for a total of eight weeks can better improve neuromuscular control and hand function in subacute stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES).

Description:

Subjects were randomly assigned into ES and control groups. Both groups received 20-minute hand function training twice a week, and the ES group received 40-minute ES on the median nerve of the affected side before each training session. The control group received sham ES - electrodes were placed on the same location but no electric current was applied. EEG, EMG and Fugl-Meyer Assessment (FMA) were collected before, at the 4th week, at the end of 8th week, and 4 weeks after the end of intervention.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: January 4, 2017
• Est. primary completion date: January 4, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

1. first-ever cerebral cortical region involved chronic stroke, onset over a month,

2. able to perform active thumb flexion on the affected side with the scores of manual muscle test at least two points, and

3. at stable medical condition for intervention

Exclusion Criteria:

1. history of other neurological disorders,

2. cognitive impairment (Mini-Mental State Examination score <24, MMSE),26

3. unable to follow orders,

4. contraindications of ES, and

5. under 20 years old

Related Conditions & MeSH terms

• Stroke

Intervention

Other:
• Electrical stimulation
sensory electrical stimulation was applied prior to upper limb functional training
• Sham electrical stimulation
electrodes were placed on the same location as the Electrical stimulation condition, but no electric current was applied

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
National Yang Ming University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fugl-Meyer Assessment for Upper Extremity	evaluate changes in upper extremity function of the stroke subjects	before intervention, four weeks after, at the end of the eight-week intervention and four weeks after the intervention period ended
Primary	EEG-EMG coherence	evaluate changes in functional connectivity between motor cortex and active muscles	before intervention, four weeks after, at the end of the eight-week intervention and four weeks after the intervention period ended