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Serum BDNF Role as a Biomarker for Stroke Rehabilitation — BDNF  

Stroke Clinical Trial

Official title:
Serum BDNF Role as a Biomarker for Stroke Rehabilitation

Clinical Trial Summary

This study aims to develop the quantitative biomarker to establish the individualized strategy in stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) acts on certain neurons of the central nervous system (CNS) helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses. BDNF in CNS can be assessed by analysing serum BDNF. The final objective of this study is to demonstrate a role of biomarker of BDNF in stroke rehabilitation to establish the individualized strategy.

Clinical Trial Description

Serum BDNF, proBDNF and MMP-9 in all participants will be measured before and after the comprehensive inpatient rehabilitation during subacute stroke phase. At 3 months after stroke onset, serum BDNF, proBDNF and MMP-9 will also be measured.

In addition, motor impairment with Fugl-Meyer assessement will be assessed at same time points with serum analysis.

We will compare potential serum biomarkers with motor impairment in stroke patients ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03164798
Study type Observational
Source Samsung Medical Center
Contact
Status Completed
Phase
Start date February 1, 2017
Completion date December 31, 2019
View Details
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