Stroke Clinical Trial
Official title:
A Randomised Trial of Non-Invasive Brain Stimulation (NIBS) in Stroke Survivors
After a stroke affecting the right side of the brain, many patients are affected by "spatial
neglect": the damage to the brain causes them to ignore the left side of their surroundings.
At its most extreme they may be unaware that they have a left side, or believe that it is
moving normally when it is in fact paralysed. In milder cases, people may be unable to
recognise touch on the left side if their right side is also being touched, or objects in
their left visual field if something is visible to their right. Neglect alters peoples'
quality of life profoundly, often renders them more dependent on others to undertake basic
activities of daily living, and makes effective rehabilitation much more difficult.
The limited success of current treatment approaches indicates gaps in understanding of the
underlying mechanisms of neglect and its recovery. Recent data suggest that the problems in
responding to the left side are a result of an imbalance of activity in those parts of the
brain responsible for deciding which side to pay attention to. It might therefore be
possible to help people with neglect by "rebalancing" the brain either by increasing
activity in the damaged side, or alternatively by reducing activity in the undamaged side.
In this pilot study, the investigators will test whether they can help by doing the second
of these things.
The investigators propose to conduct a pilot clinical trial to explore whether using
electric currents to temporarily modify the activity of specific areas of the intact side of
the brain, influences recovery from neglect, when used either alone, or in combination with
a training method that has previously appeared promising as a treatment. Brain activity will
be modified using a technique called "transcranial direct current stimulation (tDCS)", in
which small electric currents are applied to the scalp with a wire covered in damp cotton
pads. This will be done over the specific parts of the brain that are responsible for
focusing attention to one side.
The investigators will compare the clinical outcomes of four interventions (1: behavioural,
2: tDCS, 3: a combination of both and 4: control).
The investigators hope that these studies will advance their understanding of what
treatments may help people with neglect, and how they might work.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
| Recruiting |
NCT03869138 -
Alternative Therapies for Improving Physical Function in Individuals With Stroke
|
N/A | |
| Completed |
NCT04034069 -
Effects of Priming Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery After Stroke: A Randomized Controlled Trial
|
N/A | |
| Completed |
NCT04101695 -
Hemodynamic Response of Anodal Transcranial Direct Current Stimulation Over the Cerebellar Hemisphere in Healthy Subjects
|
N/A | |
| Terminated |
NCT03052712 -
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
|
N/A | |
| Completed |
NCT00391378 -
Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)
|
N/A | |
| Recruiting |
NCT06204744 -
Home-based Arm and Hand Exercise Program for Stroke: A Multisite Trial
|
N/A | |
| Active, not recruiting |
NCT06043167 -
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
|
||
| Active, not recruiting |
NCT04535479 -
Dry Needling for Spasticity in Stroke
|
N/A | |
| Completed |
NCT03985761 -
Utilizing Gaming Mechanics to Optimize Telerehabilitation Adherence in Persons With Stroke
|
N/A | |
| Recruiting |
NCT00859885 -
International PFO Consortium
|
N/A | |
| Recruiting |
NCT06034119 -
Effects of Voluntary Adjustments During Walking in Participants Post-stroke
|
N/A | |
| Completed |
NCT03622411 -
Tablet-based Aphasia Therapy in the Chronic Phase
|
N/A | |
| Completed |
NCT01662960 -
Visual Feedback Therapy for Treating Individuals With Hemiparesis Following Stroke
|
N/A | |
| Recruiting |
NCT05854485 -
Robot-Aided Assessment and Rehabilitation of Upper Extremity Function After Stroke
|
N/A | |
| Active, not recruiting |
NCT05520528 -
Impact of Group Participation on Adults With Aphasia
|
N/A | |
| Completed |
NCT03366129 -
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
|
||
| Completed |
NCT03281590 -
Stroke and Cerebrovascular Diseases Registry
|
||
| Completed |
NCT05805748 -
Serious Game Therapy in Neglect Patients
|
N/A | |
| Recruiting |
NCT05621980 -
Finger Movement Training After Stroke
|
N/A |