Stroke Clinical Trial
Official title:
Effects of Upper Limb Ischemic Postconditioning on Collateral Circulation in Young Symptomatic Intracranial Atherosclerosis
The purpose of this study is to evaluate the protective effects of upper limb ischemic postconditioning on collateral circulationin young symptomatic intracranial atherosclerosis and the baseline characteristics of trial participants, as an open, randomized controlled, prospective controlled trial.
Stroke is a common cardia-cerebrovascular disease with high morbidity, disability and
mortality rate. And more and more young patients account for the increasing morbidity. Among
them, Symptomatic intracranial atherosclerotic stenosis（sICAS）is a major cause, especially
in Asians.
Currently, traditional therapeutic methods present reluctant achievements on reducing stroke
recurrence and pose threat on patients'health because of invasive operation and severe side
effects. Therefore, other treatment methods are called for urgently. Remote ischemic
post-conditioning refers to local or distal ischemia treatment after the occurrence of
cerebral ischemia. Prior research has shown that repeatedly ischemic reperfusion have
protective effect on lowering the occurrence rate of ischemic events of patients with
carotid stenosis. However, in-depth research on cerebral protection and correlation with
collateral circulation has not been proven in an open, definitive clinical trial.
Thus, the EPIC-sICAS trial will provide important information on the protective effects of
upper limb ischemic post-conditioning on collateral circulation after cerebral Infarction.
Hopefully to present us a very meaningful way to improve the patient's quality of life.
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