Effects of tDCS on Quadriceps Strength After Stroke

Stroke Clinical Trial

— tDCS(HE)  

Official title:

a Controlled, Randomized Study Evaluating the Immediate Effect of One tDCS Session on Quadriceps Strength in Hemiparetic Patients.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02109796
• Other study ID #: 2014-A00219-38
• Status: Completed
• Phase: N/A
• First received: April 8, 2014
• Last updated: November 10, 2017
• Start date: February 19, 2015
• Est. completion date: April 30, 2017

Study information

• Verified date: November 2017
• Source: Centre d'Investigation Clinique et Technologique 805
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Previous studies show that one session of tDCS allow to improve muscle strength in hemiparetic patients in anodal condition. We test a new electrods configuration : a anodale stimulation opposite to the cortical representation area of the injured hemisphere and a simultaneous stimulation opposite to the homonyme the cortical representation area of the healthy hemisphere. This approach seems to be the best relevant electrods configuration in order to restore the inter-hemispheric balance.

We hypothesis that one session of tDCS with this electrods configuration allow to improve paretic quadriceps strength in hemiparetic patients after stroke.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: April 30, 2017
• Est. primary completion date: November 28, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• written consent

• hemiparetic patient after stroke in chronic phase (> 6 months)

• capacity to walk with or without technical assistance

• following rehabilitation program for lower limbs

Exclusion Criteria:

• patient with bilateral brain lesion, cerebellar syndrom, and apraxia and/or aphasia

• previous orthopedic surgery in paretic lower limb (<6 moths)

• usual tDCS contraindications

• pregnant woman

Related Conditions & MeSH terms

• Stroke

Intervention

Device:
• transcranial Direct current stimulation

Locations

Country	Name	City	State
France	Raymond Poincare Hospital	Garches

Sponsors (2)

Lead Sponsor	Collaborator
Centre d'Investigation Clinique et Technologique 805	Fondation Garches

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	maximum voluntary isometric strength of knee extensors	The maximum voluntary isometric strength of paretic knee extensors will be evaluated with a isokinetic dynamometer, which measure peak torque.	2 hours
Secondary	Resistive peak torque during passive knee flexion		2h
Secondary	Angle related to the resistive peak torque generation of the knee extensors		2h
Secondary	Amplitude of the interpolation twitch		2h
Secondary	EMG activation of the knee flexors and extensors during the strength evaluations (active and passive)		2h
Secondary	Functional evaluation of the gait performance and balance		2h