Effect of Daily Music Listening on Stroke Recovery

Stroke Clinical Trial

— MUKU2  

Official title:

Effect of Cognitive Stimulation on Recovery After Stroke

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01749709
• Other study ID #: 85/180/2011
• Status: Completed
• Phase: N/A
• Start date: December 2012
• Est. completion date: April 5, 2016

Study information

• Verified date: December 2021
• Source: Turku University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Single blind randomized clinical trial including 50 stroke patients to investigate the effect of daily music listening on behavioral, neural and physiological recovery. Patients are randomized (1:1:1) to listen instrumental or vocal music, or audiobooks (recorded book reading) (control). Outcome measures are change in neuropsychological tests, change in self-reported mood, structural and functional magnetic resonance imaging changes and hormonal changes performed at acute, 3-month and 6-month stages.

Description:

Please see above

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: April 5, 2016
• Est. primary completion date: April 5, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Acute Hemispheral stroke

Exclusion Criteria:

• Previous neurological or current psychiatric disease,
• severe aphasia

Related Conditions & MeSH terms

• Stroke

Intervention

Behavioral:
• Music listening

• Audiobook listening

Locations

Country	Name	City	State
Finland	Turku University Hospital	Turku

Sponsors (2)

Lead Sponsor	Collaborator
Turku University Hospital	Academy of Finland

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in neuropsychological performance (verbal memory)	Verbal memory summary score (Rivermead Behavioral Memory Test (RBMT) story recall, auditory-verbal learning task)	From acute to 3-month-stage
Primary	Change in neuropsychological performance (verbal memory)	Verbal memory summary score (RBMT story recall, auditory-verbal learning task)	From acute to 6-month-stage
Secondary	Change in neuropsychological performance (Language skill)	Verbal fluency task	From acute to 3-month-stage
Secondary	Change in neuropsychological performance (Language skill)	Naming test CERAD/Boston Naming Test (BNT)	From acute to 3-month-stage
Secondary	Change in neuropsychological performance (Language skill)	Short Token Test	From acute to 3-month-stage
Secondary	Change in neuropsychological performance (Language skill)	Verbal fluency task	From acute to 6-month-stages
Secondary	Change in neuropsychological performance (Language skill)	Naming test CERAD/BNT	From acute to 6-month-stages
Secondary	Change in neuropsychological performance (Language skill)	Short Token Test	From acute to 6-month-stages
Secondary	Change in mood	Profile of Mood States	From acute to 3-month-stage
Secondary	Change in mood	Profile of Mood States	From acute to 6-month-stage
Secondary	Change in structural gray matter	Voxel-based morphometry	From acute to 3-month-stage
Secondary	Change in structural gray matter changes	Voxel-based morphometry	From acute to 6-month-stage
Secondary	Change in structural white matter	Diffusion-weighted imaging	From acute to 3-month stage
Secondary	Change in structural white matter	Diffusion-weighted imaging	From acute to 6-month stage
Secondary	Change in neuronal function	Resting state/task-based fMRI	From acute to 3-month stage
Secondary	Change in neuronal function	Resting state/task-based fMRI	From acute to 6-month stage
Secondary	Change in physiological stress level	Cortisol serum concentration	From acute to 3-month-stage
Secondary	Change in physiological stress level	Cortisol serum concentration	From acute to 6-month-stage
Secondary	Change in physiological stress level	Beta-endorphin serum concentration	From acute to 3-month-stage
Secondary	Change in physiological stress level	Beta-endorphin serum concentration	From acute to 6-month-stage
Secondary	Change in physiological stress level	Oxytocin serum concentration	From acute to 3-month-stage
Secondary	Change in physiological stress level	Oxytocin serum concentration	From acute to 6-month-stage