Transcranial Direct Current Stimulation and Aphasia Language Therapy

Stroke Clinical Trial

Official title:

Transcranial Direct Current Stimulation and Aphasia Language Therapy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01486654
• Other study ID #: 1-kaye
• Secondary ID: 1R21DC009876-01A
• Status: Completed
• Phase: Phase 1
• First received: December 2, 2011
• Last updated: May 12, 2017
• Start date: March 2010
• Est. completion date: December 2016

Study information

• Verified date: May 2017
• Source: Rehabilitation Institute of Chicago
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effectiveness of small amounts of electrical current, applied without surgery to the brain, in combination with speech-language treatment, on the language outcome of study subjects with nonfluent aphasia (i.e. difficulty with the comprehension and expression of spoken and written language) following a stroke.

Description:

Stroke is the third leading cause of death and the most common cause of disability in the United States. According to the American Stroke Association, the prevalence of stroke in the U.S. is approximately 4.8 million with approximately 700,000 additional strokes occurring annually. Approximately 150,000 to 250,000 stroke survivors becoming severely and permanently disabled each year.

A common neurological deficit among stroke survivors, and thus a substantial contributor to post-stroke disability, is aphasia. The loss of, or difficulty with language is extremely debilitating and has enormous social and economic impact on quality of life. Presently, the only treatment available for persons with aphasia is speech-language rehabilitation.

With rehabilitation only, however, many patients achieve a less than satisfactory improvement in speech-language function, and thus are left with significant disability.

Enhancing stroke recovery by facilitating brain plasticity with the direct application of stimulation to the cerebral cortex is a new area of investigation and shows promise for improving language recovery in stroke-induced aphasia, most probably when it is combined with intense learning. There are several methods of delivering cortical brain stimulation to modulate cortical excitability, each of which have been studied in animal models with promising results, and subsequently applied to the rehabilitation of motor deficits after stroke. Applications to language problems after stroke are only emerging. Nevertheless, results suggest a potential role for cortical stimulation as an adjuvant strategy in aphasia rehabilitation.

Of the cortical stimulation methods available, transcranial direct current stimulation (tDCS) has the greatest potential for clinical use in view of its non-invasive application, ease of administration and relatively low cost. tDCS is a method of delivering weak polarizing electrical currents to the cortex via two electrodes placed on the scalp. The nature of the effect depends on the polarity of the current. Anodal tDCS has an excitatory effect; cathodal tDCS induces inhibition.

This study proposes to evaluate the safety, feasibility, and effectiveness of anodal and cathodal tDCS in study subjects with Broca's aphasia after stroke, delivered concurrent with speech-language rehabilitation.

Subjects will receive speech and language therapy combined with either anodal, cathodal, or sham stimulation applied to the lesioned left hemisphere. The polarity conditions will be compared with each other and with sham stimulation, to determine safety, the degree to which improvements in language performance occur, and the degree to which they are maintained over time.

The protocol is single-blind. Neither the subjects nor the outcomes assessor will know what stimulation the subject received until the study's conclusion; the investigator applying the stimulation will know.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

• A single unilateral left-hemisphere infarct that is confirmed by CT scan or MRI

• Nonfluent aphasia, with a mean length of utterance of 0-4 words and an Aphasia Quotient score on the Western Aphasia Battery of 25-70

• Age 21 or older

• At least 6 months post-stroke

• Premorbidly right-handed, as determined by the Edinburgh Handedness Inventory

• Premorbidly literate in English

• Completed at least an eighth grade education

• Visual acuity no worse than 20/100 corrected in the better eye

• Auditory acuity, aided in the better ear, no worse than 30 dB HL on a pure tone hearing screening (conducted at 500, 1000, 2000, and 4000 Hz.)

Exclusion Criteria:

• Any other neurological condition (other than cerebral vascular disease) that could potentially affect cognition or speech, such as Parkinson's Disease, Alzheimer's Dementia, traumatic brain injury

• Any significant psychiatric history prior to the stroke, such as severe major depression or psychotic disorder requiring hospitalization; subjects with mood disorders who are currently stable on treatment will be considered

• Active substance abuse

• Seizure disorder that precludes safe participation in this trial

• Absence of left hemisphere activation during two of the three fMRI tasks

• Presence of lesions that encompass premotor cortex from the Sylvian fissure to a point high on the convexity

Related Conditions & MeSH terms

• Aphasia
• Aphasia, Broca
• Nonfluent Aphasia
• Stroke

Intervention

Device:
• Transcranial Direct Current Stimulation - Cathodal stimulation
Cathodal transcranial direct stimulation (tDCS) to the left hemisphere, 1.0 mA for 13 minutes, is received five days a week, for six weeks, during the initial 13 minutes of 90 minutes of speech-language treatment.
• Transcranial Direct Current Stimulation - Anodal stimulation
Anodal transcranial direct stimulation (tDCS) to the left hemisphere, 1.0 mA for 13 minutes, is received five days a week, for six weeks, during the initial 13 minutes of 90 minutes of speech-language treatment.
• Transcranial Direct Current Stimulation - Sham stimulation
Sham stimulation provided together with 90 minutes of speech language therapy, 5 days a week, for 6 weeks.

Locations

Country	Name	City	State
United States	Center for Aphasia Research & Treatment, Rehabilitation Institute of Chicago	Chicago	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
Rehabilitation Institute of Chicago	National Institute on Deafness and Other Communication Disorders (NIDCD)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Aphasia Quotient (AQ) on the Western Aphasia Battery		Change from Baseline in Western Aphasia Battery at 6 weeks
Secondary	Functional communication skills	Scores derived from language sample analyses	Change from Baseline in functional communication skills at 6 weeks
Secondary	Participation in everyday activities	Measures on CETI, BOSS, CCRSA	Change from Baseline in participation in everyday activities at 6 weeks
Secondary	Western Aphasia Battery - Reading and Writing scores		Change from Baseline in Western Aphasia Battery Reading and Writing scores at 6 weeks
Secondary	Western Aphasia Battery Aphasia Quotient (Maintenance)		Change in Western Aphasia Battery AQ from 6 weeks to 12 weeks
Secondary	Western Aphasia Battery Reading and Writing Scores (Maintenance)		Change in WAB Reading and Writing Skills from 6 weeks to 12 weeks
Secondary	Functional Communication Skills (Maintenance)		Communication skills from 6 weeks to 12 weeks
Secondary	Participation in everyday activities (Maintenance)		Change in participation in everyday activities from 6 weeks to 12 weeks