Transformation of Somatosensory and Visual Coordinate Systems

Stroke Clinical Trial

Official title:

The Transformation of Coordinates Between Somatosensory and Visual Systems: a Neurophysiological Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01177462
• Other study ID #: CMRPG590021G
• Status: Recruiting
• Phase: N/A
• First received: July 29, 2010
• Last updated: September 23, 2013
• Start date: March 2011

Study information

• Verified date: September 2013
• Source: Chang Gung Memorial Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Manipulation of object is a multisensory experience that includes tactile motion between the object and the fingerpad, visual motion elicited by the motion the object and the movement of the hand, and the active motor commend to control upper limb and hand conformation. It remains to be determined how such a complex interaction between touch and vision could be achieved effortlessly. In the present study, we will investigate how the motion information is transformed between touch and vision using the most novel approaches in human psychophysics, neuropsychology and monkey neurophysiology. Specifically, we will present tactile motion on primate fingerpads using a recently developed ball stimulator with a design in which we vary the direction of motion with respect to the skin surface and also vary the hand conformation and position. This setup allows us to systematically sample the possible scenarios involving coordinate transformation between the somatosensory and visual systems in conditions that could occur in hand exploration and object manipulation in daily life. We will present these tactile stimuli on normal human subject as well as stroke patients such as patients with spatial hemineglect. Finally, we will record from macaque monkeys in cortical areas that are thought to underlie the transformation of coordinates, such as the primary somatosensory cortex and posterior parietal cortex. The results of the present study will contribute to the understanding of multisensory integration and the rehabilitation for patients with impaired use of spatial information.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 90
• Est. primary completion date: December 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

For stoke patients

Inclusion Criteria:

• stroke patients

• stable medical condition

• can cooperate in evaluation

Exclusion Criteria:

• peripheral neuropathy

• limb ambulation

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Stroke

Locations

Country	Name	City	State
Taiwan	Chang Gung Memorial Hospital	Taoyuan County

Sponsors (1)

Lead Sponsor	Collaborator
Chang Gung Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Perceived direction of tactile motion	Detail description for time frame of assessment: (1) for stroke patients, the assessment will be performed "in average" 6 months after the onset of stroke (2) for normal subjects: assessment will be done when the subject is willing to participate (3) the subject might come to the lab more than once if the experiment can not be completed in one session; Assessment: We present tactile motion using tactile stimulators to (1)different digits (2)different hand conformations and (3) different hand positions relative to the trunk	Once; specifically for stroke patients, 6 months after the onset of stroke	No