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Autoimmune Phenomena After Acute Stroke — ARIMIS  

Stroke Clinical Trial

Official title:
Autoimmune Phenomena After Acute Stroke - the Role of Stroke-induced Immunodepression

Clinical Trial Summary

The damage of the brain parenchyma, as well as the stroke-induced dysfunction of the blood-brain-barrier can make previously hidden CNS antigens "visible", and can thus lead to the development of autoimmune mechanisms.

It seems plausible that stroke-associated immunodepression influences the development and the phenotype of these autoreactive immune responses.

This study will investigate whether cerebral ischemia leads to changes in the immune response, in particular to the development and/or proliferation of autoreactive effector T-cells and/or regulatory T-cells. Furthermore, the association between the severity and the phenotype of this autoimmune response and the clinical course, i.e. prognosis and mortality, will be investigated.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01082783
Study type Observational
Source Charite University, Berlin, Germany
Contact
Status Completed
Phase
Start date December 2009
Completion date November 2011
View Details
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