Stroke Clinical Trial
Official title:
Balance Recovery and Training on Fall Prevention in Stroke
The specific aims of this research are delineated as the following:
Aim 1: To investigate the neuromuscular and biomechanical mechanisms of the emerging
processes of proactive and reactive balance control during sitting and standing in patients
with stroke at different stages of the recovery course.
Aim 2: To determine the relationships between brain lesion sites and the recovery patterns
of reactive and proactive balance control mechanisms in patients with stroke.
Aim 3: To determine the relationships between the impairments in reactive and proactive
balance control mechanisms and functional outcome as well as fall incidence in patients
following stroke.
Aim 4: To investigate the efficacy of different training regimens in improving reactive and
proactive balance control strategies and in preventing falls in stroke patients with
different brain lesion sites.
Principally, three hypotheses are to be tested:
Hypothesis 1:The emerging processes and recovery patternes of proactive and reactive balance
control may be different among stroke patients with different brain lesion locations.
Hypothesis 2:There are positive correlations between the level of impairments in reactive
and proactive balance control mechanisms and functional outcome as well as fall incidence in
patients following stroke.
Hypothesis 3:Training regimens that could best facilitate the emergence or improvement in
reactive and proactive balance control strategies are different.
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | December 2007 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 45 Years to 75 Years |
Eligibility |
Inclusion Criteria: Healthy subjects - Age ang Sex are correspond with the stroke subjects(between 45 and 75 years old) - having the habit of regular exercise (at least twice a week, and at least 20 minutes duration each time) - being willing to accept one-year follow-up examination - being willing to sign an informed consent approved by the Human Subjects Committee of the National Taiwan University Hospital Stroke subjects - between 45 and 75 years old - cerebral infarction stroke confirmed by ICD-10-CM and brain imaging diagnosis(including I63.0, I63.1, I63.2, I63.3, I63.4, I63.5, I63.6, I63.8, and I63.9) - first stroke and received acute treatment at NTUH - being willing to accept one-year follow-up examination - being willing to sign an informed consent approved by the Human Subjects Committee of the National Taiwan University Hospital Exclusion Criteria: Healthy subjects - having other neurological diseases, or moderate to severe neuromuscular or musculoskeletal disorders, or disorders from systematic diseases those would influence the belance or motor ability Stroke subjects - on the 14st day after stroke onset, having unstable vital sign, unconsciousness, or obvious cognitive, perception, and language impairment, and couldn't communicate with the experimenters - having other neurological diseases, or moderate to severe neuromuscular or musculoskeletal disorders, or disorders from systematic diseases other than stroke |
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Educational/Counseling/Training
Country | Name | City | State |
---|---|---|---|
Taiwan | School and Graduate Institute of Physical Therapy College of Medicine, National Taiwan University | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital | National Health Research Institutes, Taiwan |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To investigate the balance recovery(proactive postural adujustments and reactive postural reaction) post-onset of each stroke subject | |||
Secondary | To investigate the incidence of falls before and after training |
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