Stroke Clinical Trial
Official title:
Theta-Burst-Stimulation in Recurrent Stroke Recovery
The present study aims at investigating the effects of intermittent theta-burst stimulation (iTBS) for motor recovery in recurrent stroke patients. Therefore a daily intervention of repetitive transcranial magnetic stimulation over 8 days combined with subsequent physiotherapy is compared to a control condition, sham stimulation combined with subsequent physiotherapy. Motor function, degree of disability and quality of life are examined in order to evaluate the effects of iTBS in the rehabilitation of recurrent stroke patients in the first weeks and after three months.
To date, the majority of neuromodulation approaches aiming at improving motor recovery after
stroke are limited to patients with first-ever ischemic stroke. Therefore, rehabilitation of
recurrent stroke mainly includes physiotherapy and occupational therapy. Yet, particular
these patients retain movement impairment relevant for activities of daily living.
By using repetitive transcranial magnetic stimulation (rTMS), it is possible to promote
recovery of connectivity between brain regions, particularly after stroke and thereby improve
motor performance. Previous data indicate that intermittent theta-burst stimulation (iTBS), a
protocol of neuromodulation, enhances the effects of subsequent motor training in early
rehabilitation after stroke.
The current study aims at investigating whether daily repetitive transcranial magnetic
stimulation over 8 days combined with subsequent physiotherapy leads to better motor recovery
in recurrent stroke, compared to control condition, physiotherapy after sham stimulation.
Motor function, degree of disability and quality of life are examined in order to evaluate
the effects of iTBS in the rehabilitation of recurrent stroke patients in the first weeks and
after three months.
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