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N-ACETYLCYSTEINE FOR THROMBOLYSIS IN ACUTE STROKE — NAC-S  

Stroke, Ischemic Clinical Trial

Official title:
TOLERANCE STUDY OF N-ACETYLCYSTEINE FOR THROMBOLYSIS IN THE ACUTE PHASE OF ISCHEMIC STROKE / ETUDE DE TOLERANCE DE LA N-ACETYLCYSTEINE POUR LA THROMBOLYSE A LA PHASE AIGUË DE L'INFARCTUS CEREBRAL

Clinical Trial Summary

The primary objective of the study is to assess the safety of N-Acetylcysteine as a thrombolytic agent in acute ischemic stroke, especially regarding the risk of hemorrhagic transformation.

Clinical Trial Description

Preclinical studies demonstrated that N-Acetylcysteine (NAC) is able to break von Willebrand Factor (VWF) multimers by bisulfide bond reduction. Since thrombi in stroke patients are rich in VWF, NAC could be used as a thrombolytic agent during the acute phase. This study aims at assessing the safety of NAC in combination with alteplase (rt-PA) at the acute phase of ischemic stroke. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04920448
Study type Interventional
Source University Hospital, Caen
Contact Marion Boulanger, MD, PhD
Phone +33231064617
Email boulanger-ma@chu-caen.fr
Status Not yet recruiting
Phase Phase 2
Start date June 7, 2021
Completion date September 7, 2022
View Details
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