Validation of DRAGON Versus a Simplified DRAGON/Machine Learning

Status Recruiting

Clinical Trial Summary

The CT-DRAGON score can predict long-term functional outcome after acute stroke treated by thrombolysis. However, implementation in clinical practice is hampered by a lack of validation in the broad spectrum of stroke patients undergoing thrombectomy, whether or not in combination with thrombolysis or conservative treatment. Furthermore, the CT-DRAGON score considers multiple items, which are not always readily available in every setting. This study aims to investigate whether either a simplified version of the CT-DRAGON score with only three clinical items or a machine learning technique could be as powerful and more feasible.

Clinical Trial Description

The investigators aim to validate the CT-DRAGON score in all ischaemic stroke localisations and for all treatment options, including a conservative treatment policy. The predictability will then be compared with on the one hand simplified prognostic models that include only a selective set of highly predictive parameters that have already been described in the literature, such as patient age, National Institutes of Health Stroke Scale (NIHSS) and pre-stroke modified Rankin Scale (mRS). On the other hand, machine learning techniques, that incorporate a large set of variables and have recently shown some promising results, will also be applied to predict long-term outcome after ischaemic stroke. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04092543
Study type	Observational
Source	Ziekenhuis Oost-Limburg
Contact	Dieter Mesotten, MD PhD
Phone	+3289325407
Email	elly.vandermeulen@zol.be
Status	Recruiting
Phase
Start date	March 1, 2019
Completion date	November 1, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05378035` - DOAC in Chinese Patients With Atrial Fibrillation
Completed	`NCT03574038` - Transcranial Direct Current Stimulation as a Neuroprotection in Acute Stroke	N/A
Completed	`NCT03679637` - Tablet-based Aphasia Therapy in the Acute Phase After Stroke	N/A
Completed	`NCT03633422` - Evaluation of Stroke Patient Screening
Completed	`NCT04088578` - VNS-supplemented Motor Retraining After Stroke	N/A
Withdrawn	`NCT04991038` - Clinical Investigation to Compare Safety and Efficacy of DAISE and Stent Retrievers for Thrombectomy In Acute Ischemic Stroke Patients	N/A
Not yet recruiting	`NCT05534360` - Tenecteplase Treatment in Ischemic Stroke Registry
Not yet recruiting	`NCT04105322` - Effects of Kinesio Taping on Balance and Functional Performance in Stroke Patients	N/A
Withdrawn	`NCT05786170` - ERILs Und SNILs Unter SOC	N/A
Recruiting	`NCT03132558` - Contrast Induced Acute Kidney in Patients With Acute Stroke	N/A
Completed	`NCT02893631` - Assessment of Hemostasis Disorders in rtPA-treated Patients Requiring Endovascular Treatment for Ischemic Stroke
Active, not recruiting	`NCT02274727` - Biomarker Signature of Stroke Aetiology Study: The BIOSIGNAL-Study
Completed	`NCT02225730` - Imaging Collaterals in Acute Stroke (iCAS)
Terminated	`NCT01705353` - The Role of HMGB-1 in Chronic Stroke	N/A
Active, not recruiting	`NCT01581502` - SAMURAI-NVAF Study: Anticoagulant Therapy for Japanese Stroke Patients With Nonvalvular Atrial Fibrillation (NVAF)	N/A
Completed	`NCT01182818` - Fabry and Stroke Epidemiological Protocol (FASEP): Risk Factors In Ischemic Stroke Patients With Fabry Disease	N/A
Completed	`NCT00761982` - Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.	Phase 1/Phase 2
Completed	`NCT00535197` - Autologous Bone Marrow Stem Cells in Ischemic Stroke.	Phase 1/Phase 2
Terminated	`NCT00132509` - FRALYSE Trial: Comparison of the Classical Rt-PA Procedure With a Longer Procedure in Acute Ischemic Stroke	Phase 2
Recruiting	`NCT05760326` - Diagnostic and Prognostic Role of Clot Analysis in Stroke Patients