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NCT03933358 Clinical Trial

Effect of Thyroid Hormone on Post-Myocardial Infarction Remodeling and Prognosis in STEMI Patients

STEMI Clinical Trial

— ThyREST  

Official title:
Effect of Thyroid Hormone on Post-Myocardial Infarction Remodeling and Prognosis in STEMI Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03933358
Other study ID # BFH-Thyroid and STEMI
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 1, 2019
Est. completion date June 30, 2021

Study information
Verified date May 2019
Source Beijing Friendship Hospital
Contact Hongwei Li
Phone 0086 10 63139780
Email lhw19656@sina.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study aims to determine whether thyroid hormone levels are predictive of cardiac remodeling following myocardial infarction and the prognosis in patients with STEMI receiving primary percutaneous coronary intervention.

Recruitment information / eligibility
Status Recruiting
Enrollment 250
Est. completion date June 30, 2021
Est. primary completion date June 30, 2021
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- with a confirmed STEMI diagnosis

- undergoing primary percutaneous coronary intervention (presenting <12h after symptom onset)

- patients agreed and provided informed consent

Exclusion Criteria:

- past history of myocardial infarction or percutaneous coronary intervention or coronary artery bypass graft

- past history of heart failure (LVEF<40%) or myocardiopathy or atrial fibrillation

- past history of thyroid diseases, or were treated with amiodarone, dopamine, or corticosteroids before hospital admission

- contraindicating to cardiac magnetic resonance imaging

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Thyroid hormone levels
This is an observational study. Exposure: Different thyroid hormone levels.

Locations
Country Name City State
China Beijing Friendship Hospital, Capital Medical University Beijing

Sponsors (1)
Lead Sponsor Collaborator
Beijing Friendship Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary MACE (major adverse cardiovascular events) cardiovascular death, re-infarction, revascularization, and stroke 12 months
Secondary adverse cardiac remodeling a cut-off value of 12% change in left ventricular end-diastolic volume between the acute and follow-up magnetic resonance scans 6 months
Secondary all-cause death death caused by all reason 12 months
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