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Spasticity clinical trials

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NCT ID: NCT02114736 Recruiting - Stroke Clinical Trials

Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke

Start date: March 2014
Phase: Phase 4
Study type: Interventional

Stiff knee gait is defined as the lack of knee flexion in the swing phase of gait. Stiff knee gait is a frequent condition among stroke patients leading to reduce gait speed and increase energy cost. In association with neuro-rehabilitation, botulinum toxin A injections in the rectus femoris is recommended. However, the botulinum toxin A effect is transient necessitating repeated injections. The aim of this study is to compare the benefit of the rectus femoris tenotomy in comparison with botulinum toxin A injections according to the 3 domains of the International Classification of Functioning Disability and Health of the World Health Organisation

NCT ID: NCT02073513 Completed - Spasticity Clinical Trials

Kinesiotaping the Hand in Cerebral Palsy

Start date: November 2009
Phase: N/A
Study type: Interventional

BACKROUNDS: Thumb in palm deformity restricts hand function by prevent somatosensory input in the children with cerebral palsy who have spasticity in their hands. OBJECTÄ°VES: To investigate the effects of thenar palmar kinesiotape application with and without pressure on hand function in children with cerebral palsy. METHOD: 45 children were randomly allocated to one of the thenar taping groups either with or without pressure or to the control group. Nine hole peg test and nine parts puzzle test were used to measure hand function. The two study groups were evaluated initially, with taping 20 minutes later and 20 minutes after taping was removed.

NCT ID: NCT02027025 Completed - Spasticity Clinical Trials

Study of SPARC1103 in Subjects With Spasticity

Start date: April 21, 2014
Phase: Phase 2
Study type: Interventional

Study of SPARC1103 in subjects with spasticity

NCT ID: NCT02002884 Completed - Cerebral Palsy Clinical Trials

Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy

XARA
Start date: March 28, 2014
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of one or both arms alone or in combination with injections into one or both legs are effective and safe in treating children/adolescents (age 2-17 years) with increased muscle tension/uncontrollable muscle stiffness (spasticity) due to cerebral palsy.

NCT ID: NCT01964547 Completed - Multiple Sclerosis Clinical Trials

A Randomized Study of Sativex on Cognitive Function and Mood: Multiple Sclerosis Patients

Start date: January 2012
Phase: Phase 4
Study type: Interventional

A study to compare the change in cognitive performance and psychological status of patients with spasticity due to Multiple Sclerosis when treated with Sativex or placebo, added to existing anti-spasticity therapy over a period of 48 weeks. Secondary objectives were to evaluate the effect of Sativex on mood and spasticity and to assess the safety and tolerability of Sativex.

NCT ID: NCT01945684 Completed - Stroke Clinical Trials

A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticity

Start date: September 2013
Phase: Phase 3
Study type: Interventional

Purpose: This study is a Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb(wrist, finger, elbow, thumb)Spasticity.

NCT ID: NCT01915459 Completed - Stroke Clinical Trials

Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticity

Start date: June 2013
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of Botulax® compared to Botox® reducing upper limb muscle tone in post stroke patients.

NCT ID: NCT01879449 Completed - Spasticity Clinical Trials

Prevalence of Spasticity in Veterans Living in a Long-term Care Facility

Start date: February 2013
Phase: N/A
Study type: Observational

The purpose of the study is to conduct a feasibility survey of the prevalence of spasticity at a single long-term care facility for veterans and their spouses in Murfreesboro, Tennessee. These data will be used to strengthen a future grant application to the Department of Defense in response to their ongoing Traumatic Brain Injury initiative.

NCT ID: NCT01868048 Withdrawn - Multiple Sclerosis Clinical Trials

Phase 3, 28-week, Randomized, Double-blind, Placebo-controlled Safety and Efficacy Study of Nabiximols as an add-on Therapy in Subjects With Spasticity Due to Multiple Sclerosis.

Start date: n/a
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the effective dose range and to demonstrate a non-effective dose range of Sativex compared with placebo in relieving symptoms of spasticity due to multiple sclerosis.

NCT ID: NCT01844232 Completed - Multiple Sclerosis Clinical Trials

One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spasticity

Start date: April 2013
Phase: Phase 3
Study type: Interventional

Clinical protocol OS440-3003 is a multicenter, open-label, non-randomized, uncontrolled, dose escalation study to evaluate the safety and tolerability of Arbaclofen Extended Release Tablets over 1 year in Multiple Sclerosis (MS) subjects with spasticity. All subjects in this study will receive arbaclofen in the extended release tablet formulation.