HIV Clinical Trial
Official title:
Somatosensory Deficiencies Affect Postural Stability in Asymptomatic Individuals With HIV
Persons with HIV can present vestibular system impairments, affecting postural stability. There is scarce literature related to the contribution of the visual and somatosensory systems in maintaining postural stability in persons with HIV. The purpose of this study is to describe the sensory systems used to maintain postural stability and how the sources of sensory information contributes to postural stability in asymptomatic persons with HIV. Postural stability was measured in 20 asymptomatic persons with HIV (11 male, 9 female, aged 43 ± 8 years). Static postural stability was evaluated during eight conditions that perturbed the visual, somatosensory and vestibular inputs. A paired-samples t-test was conducted to compare center of pressure (COP), antero-posterior displacement (APD) and right-left displacement (RLD) on stable and unstable surface and to characterize each balance sensory system. There was a significant difference in the COP and APD of eyes open condition compared to the remaining conditions on stable surface. Furthermore, there was a significant difference in the COP, APD and RLD for the eyes open on a foam surface compared to the remaining conditions on an unstable surface. Postural instability can be detected in asymptomatic persons with HIV under challenging conditions, previous to the evident appearance of balance impairments.
The institutional review boards (IRB) of the University of Puerto Rico Medical Science
Campus, reviewed and approved this study before any data collection was initiated. An
informed consent was provided to each subject to access their medical records, HIV status,
CD4+ cell count and as a requirement to participate in the study.
The subjects were recruited from La Perla de Gran Precio (Community wellness center that
specializes in individuals with HIV) localized in San Juan, Puerto Rico. Each subject was
evaluated by interview and review of their medical record for the inclusion and exclusion
criteria assessment. Different tests were performed as a screening tool to identify
additional limitations or impairments in the different sensory systems. To rule out severe
neuropathy, the subject had to be able to detect a Semmes- Weinstein Monofilament of 5.07 or
less in more than two areas of the foot.12,13 The visual system was screened using Snellen
chart and the subject had to obtain at least 20/40 of visual acuity. To rule out severe
balance impairments, the Romberg Test and Fukuda's Stepping Test were used. For Romberg Test,
subjects had to maintain standing position for 30 seconds and Fukuda's Stepping Test required
that the subject did not rotate more than 30° from the initial position or deviate more than
0.5 meters from the center of the circle. Functional strength of lower extremities was
screened using a Five Times Sit to Stand test, where the subject had to complete the test in
10 seconds or less. Severe proprioception impairments were assessed using a Proprioceptive
Awareness test, where the subject was asked to replicate the initial position performed by
the evaluator in the contralateral ankle joint in three trials. After the screening of the
inclusion and exclusion criteria, a total of 20 subjects were able to participate in the
study.
Each subject was instructed to stand in a static bipedal posture on the MatScan® pressure mat
and performed eight balance tasks. Data of center of pressure, antero-posterior sways and
medial-lateral sways were collected in each of the conditions. Each task took 30 seconds to
be performed. The first four tasks were performed with the mat on the hard surface of the
floor. These four tasks are as follows:1) eyes open looking at a fixed point to evaluate all
systems (EO); 2) eyes closed (with head fixed approximately 90˚) to eliminate visual input
(EC); 3) eyes open looking at a fixed point and actively moving head upward and downward to
alter vestibular inputs (EO+HUD). The subject was instructed to maintain a movement frequency
of 60bpm and amplitude of approximately 45 degrees in each direction: neck flexion and
extension; 4) eyes closed (with head fixed approximately 90˚) to eliminate visual input and
the head actively moves upward and downward to alter vestibular inputs (EC+HUD). The subject
is instructed to maintain the movement frequency and amplitude as described in task 3.
The subjects were asked to perform four more tasks while standing on a thick piece of balance
foam that was placed on top of the MatScan®, creating an unstable surface. The remaining four
tasks (tasks 5-8) are as follows: 5) eyes open looking at a fixed point while standing on the
balance foam to alter somatosensory inputs (EO+BF); 6) eyes closed with head fixed
approximately 90˚ while standing on the balance foam to alter somatosensory inputs and
eliminate visual inputs (EC+BF); 7) eyes open looking at a fixed point and actively moving
the head upward and downward while standing on the balance foam to alter somatosensory and
vestibular inputs (EO+HUD+BF). The subject was instructed to maintain the movement frequency
and amplitude as described in task 3; 8) eyes closed with head fixed approximately 90˚ and
actively move head upward and downward while standing on the balance foam to eliminate visual
inputs and alter somatosensory and vestibular inputs (EC+HUD+BF). The subject is instructed
to maintain the movement frequency and amplitude as described in task 3.
Data of postural stability was obtained using the MatScan® pressure mat (TekScan, Boston,
MA). The data collected from the pressure mat was analyzed with Tekscan Sway Analysis Module™
(SAM) software (TekScan, Boston, MA) designed for this purpose. Mean and standard deviation
were used to describe data. The statistical software used was SPSS-20 to perform a
Paired-Samples t-test and compare the center of pressure, antero-posterior and right-left
body sways displacement. P values <0.05 were accepted as statistically significant.
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