Soft Tissue Sarcoma Clinical Trial
Official title:
Peripheral Circulating Blood Tumor Cells (CTC) Detection and CTC-based PD-L1 Antibody Immunofluorescence Detection to PD-1 Monoclonal Antibody SHR-1210 and Apatinib in Second-line and Back-line Treatment of Advanced NSCLC, Soft Tissue Sarcoma, Uterine Cancer Clinical Research
In this one-arm study, histologically or cytologically confirmed advanced NSCLC, uterine malignancies, and soft tissue sarcoma will be enrolled to investigate the efficacy and safety of PD-1 monoclonal antibody SHR-1210 and apatinib, at the same time, peripheral circulating blood tumor cells (CTC) detection and CTC-based PD-L1 antibody immunofluorescence detection will be performed.
Primary outcome:
1. Analysis of baseline levels of CTC and CTC PD-L1 and prognosis efficacy of patients:
Objective remission rate (ORR), progression free survival (PFS), overall survival (OS);
2. Dynamic monitoring of CTC and CTC PD-L1 at baseline before treatment, after two cycles
of treatment, and as the disease progresses.
3. Consistency analysis of PD-L1 and CTC PD-L1 expression in tissue specimens.
Secondary outcome:
Duration of response(DOR), Disease control rate(DCR), Safety of the combination therapy.
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